[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613565":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":25,"responsibleParty":41,"collaborators":25,"id":45,"slug":25,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":25,"enrollmentInfo":54,"targetDuration":25,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":70,"whyStopped":25,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":25},{"fullName":5,"class":6},"Rutgers, The State University of New Jersey","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"1-hour Premedication Protocol","EXPERIMENTAL","IV glucocorticoid and antihistamine 1 hour before contrast",[13],"Other: IV glucocorticoid and antihistamine",{"label":15,"type":16,"description":17,"interventionNames":18},"4-hour Premedication Protocol","ACTIVE_COMPARATOR","IV glucocorticoid 4 hours before contrast and IV antihistamine 1 hour before contrast",[19],"Other: IV glucocorticoid and antihistamine (standard of care)",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"IV glucocorticoid and antihistamine","Methylprednisolone sodium succinate (e.g., Solu-Medrol®) 40 mg IV immediately plus diphenhydramine 25 mg IV 1 hour before contrast medium administration for CT imaging",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"IV glucocorticoid and antihistamine (standard of care)","Methylprednisolone sodium succinate (e.g., Solu-Medrol®) 40 mg IV immediately 4 hours before contrast medium administration, plus diphenhydramine 25 mg IV 1 hour before contrast for CT imaging",[15],[31],{"name":32,"affiliation":33,"role":34},"Paul Peng","Rutgers Robert Wood Johnson Medical School","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Chirag N Shah, MD","CONTACT","732-235-8717","shahcn@rwjms.rutgers.edu",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Paul Peng, MD PhD MSCR","Assistant Professor","100613565",false,"NCT07268248","1-hour Premedication for Allergy Goal in Emergency: PAGE-1 Study","1-hour Premedication for Allergy Goal in Emergency Computed Tomography, A Randomized Controlled Non-inferiority Trial: PAGE-1 Study","PAGE1","Inclusion Criteria:\n\n1. Adult (≥ 21 years old)\n2. Documented iodinated contrast allergy in the electronic health record\n3. CT with iodinated contrast ordered for a high-risk indication, † defined as post-arrest, concern for aortic dissection, ischemia, occlusion, obstruction, or other life-threatening conditions requiring timely diagnosis\n4. Willing and able to give consent\n\nExclusion Criteria:\n\n1. Previous enrollment in this study\n2. Pregnancy\n3. Seafood or iodine allergy, alone\n4. Gadolinium allergy","ALL","21 Years",{"count":55,"type":56},540,"ESTIMATED","INTERVENTIONAL",[59],"NA","1-hour Premedication for Allergy Goal in Emergency: PAGE-1 is a prospective, parallel, two-arm, non-inferiority, randomized controlled trial evaluating the safety of a 1-hour (intervention) versus a 4-hour (standard regimen) intravenous (IV) premedication protocol in adult patients in the Emergency Department (ED) with a documented iodinated contrast allergy and requiring computed tomography (CT) imaging for a high-risk indication.",[62,63,64,65],"Allergic Reaction to Contrast Media","Hypersensitivity Reaction","Computed Tomography","Premedication",[67,68,69],"Iodinated Contrast Reaction","Contrast-enhanced CT","Glucocorticoid prophylaxis","NOT_YET_RECRUITING","2026-02-16",{"date":73,"type":74},"2026-02-19","ACTUAL",{"date":76,"type":56},"2026-06",{"date":78,"type":56},"2028-06",{"name":43,"class":6}]