[18F]F-FAPI PET-CT to Identify Carcinoma of Unknown Primary Origin
ConditionCancer of Unknown Primary
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-99
SponsorErasmus Medical Center
About this trial
The investigators will determine the proportion of CUP patients in whom the primary tumor can be identified by \[18F\]F-FAPI PET-CT.
Eligibility criteria
Qualifiers
Age ≥ 18 years old
Histologically-confirmed metastatic disease without identification of a primary tumor after standard diagnostic work-up, according to the national care pathway for CUP (in Dutch: Regionaal Zorgpad Primaire Tumor Onbekend), which includes at least an [18F]FDG PET-CT.
Disqualifiers
Patients with metastasis from a known primary tumor.
Sarcomas, melanomas, germ cell tumors, neuroendocrine tumors and haematological malignancies whose exact site of origin is not established.
History of malignancy within 5 years prior to [18F]F-FAPI PET-CT scan, with the exception of the cancer under investigation in this study and malignancies with a negligible risk of metastasis or death (e.g., 5-year OS rate > 90%), such as adequately treated carcinoma in-situ of the cervix, nonmelanoma skin carcinoma, localized prostate cancer, ductal carcinoma in-situ, or Stage I uterine cancer.
Prior systemic therapy for the treatment of CUP.
Trial design
Treatments tested in this trial
- [18F]F-FAPI PET-CT
Treatment groups
50 Participants
are divided into 1 treatment groupLocations
6Antoni van Leeuwenhoekziekenhuis Amsterdam Netherlands
UMC Groningen Groningen Netherlands
Maastricht UMC Maastricht Netherlands
Radboud UMC Nijmegen Netherlands
Sponsors and collaborators
Erasmus Medical Center
Lead sponsor
Dutch Cancer Society
Collaborator
Academisch Ziekenhuis Maastricht
Collaborator
Missie Tumor Onbekend
Collaborator
Noordwest Ziekenhuisgroep
Collaborator
Cyclotron Noordwest BV
Collaborator
Source ClinicalTrials.gov