[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641024":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":37,"collaborators":41,"id":44,"slug":10,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":56,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":72},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Early maintenance treatment group",null,"Drug (quetiapine, 400mg\u002Fd) during the 12-month randomized phase of the study",{"label":13,"type":10,"description":14,"interventionNames":10},"Early discontinuation group","Drug (placebo) during the 12-month randomized phase of the study",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Lai Ming Christy Hui, PhD","CONTACT","852-22554486","christy@lmhui.com",[22],{"facility":23,"status":24,"city":25,"state":10,"zip":10,"country":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Department of Psychiatry, Queen Mary Hospital","RECRUITING","Hong Kong","China",{"type":28,"coordinates":29},"Point",[30,31],114.17469,22.27832,{"lat":31,"lon":30},[34],{"name":35,"role":18,"phone":36,"phoneExt":10,"email":20},"Christy Lai-ming Hui, Dr","+852 2255 3064",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dr. Christy Lai-ming Hui","Associate Professor",[42],{"name":43,"class":6},"Research Grants Council, Hong Kong","100641024",false,"NCT07616999","A 20-Year Follow-up of First Episode Psychosis: Longitudinal Effects of Early Treatment Strategies and Relapse","Navigating the Longitudinal Effects of Early Treatment Strategies and Relapse on Clinical, Cognitive, and Functional Outcomes: A 20-Year Follow-up of First Episode Psychosis","Participants were individuals who previously participated in a randomized controlled trial investigating medication continuation\u002Fdiscontinuation on relapse during first episode psychosis (ClinicalTrials.gov NCT00334035). The trial included specific inclusion and exclusion criteria, detailed as follows:\n\nInclusion Criteria:\n\n* A diagnosis of schizophrenia or non-affective psychosis (schizophreniform disorder, schizoaffective disorder, brief psychotic disorder, or psychosis not otherwise specified) (DSM-IV)\n* Aged 18 to 65 years at the time of original enrolment\n* Had been treated with antipsychotic drugs for at least 12 months\n* No history of relapse or exacerbation or had to be asymptomatic (free of positive symptoms of psychosis) at study entry.\n\nExclusion Criteria:\n\n* A diagnosis of drug-induced psychosis\n* Current treatment with clozapine, with mood stabilizing medications (lithium, valproate or carbamazepine) or with depot medication\n* Had high risk of suicide or violence\n* Inability to provide informed consent at recruitment","ALL","18 Years","65 Years",{"count":54,"type":55},178,"ESTIMATED","20 Years","OBSERVATIONAL","The study aims to address the following questions:\n\n1. Do subgroups defined by early medication choices, relapse, and medication taken over 20 years differ in clinical, cognitive, and functional outcomes?\n2. What are the long-term cognitive functioning trajectories, what factors predict these trajectories, and how do they relate to outcomes?\n3. What might be the mechanisms behind medication discontinuation and poor long-term outcome, including the roles of multiple relapses and treatment resistance after first-episode psychosis?\n\nEligible patients will be invited to a one-time face-to-face interview. A trained research assistant will guide the participants through questions about their background, clinical symptoms, daily functioning, cognitive abilities, and psychological well-being.",[60],"Schizophrenia",[60,62],"20-year follow up","2026-06-23",{"date":65,"type":66},"2026-06-26","ACTUAL",{"date":68,"type":66},"2026-05-21",{"date":70,"type":55},"2028-12-31",{"name":5,"class":6},1]