[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100142762":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":23,"centralContacts":27,"locations":34,"responsibleParty":50,"collaborators":10,"id":52,"slug":10,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University Hospital, Lille","OTHER",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"BMI ≥ 35 kg\u002Fm2 and diabetes",null,"BMI (Body Mass Index) ≥ 35 kg\u002Fm2 and diabetes defined by a fasting blood glucose ≥ 7 mmol\u002Fl and\u002For ≥ to 11.1 mmol\u002Fl, 120 minutes after ingestion of glucose (oral glucose tolerance test)",{"label":13,"type":10,"description":14,"interventionNames":10},"BMI ≥ 35 kg\u002Fm2 with intolerance glucose","BMI (Body Mass Index) ≥ 35 kg\u002Fm2 with intolerance glucose defined by a fasting blood glucose\\> 6 mmol\u002FL and \\\u003C7 mmol\u002Fl and \u002F or\\> 7.8 mmol\u002Fl and \\\u003C11.1 mmol\u002Fl , 120 minutes after ingestion of glucose (oral glucose tolerance test)",{"label":16,"type":10,"description":17,"interventionNames":10},"BMI ≥ 35 kg\u002Fm2 without diabetes","BMI (Body Mass Index)≥ 35 kg\u002Fm2 without diabetes defined by a blood glucose ≤ 6 mmol\u002FL and \u002F or ≤ 7.8 mmol\u002Fl, 120 minutes after ingestion of glucose (oral glucose tolerance test)",{"label":19,"type":10,"description":20,"interventionNames":10},"BMI \u003C27 kg\u002Fm2 without diabetes","BMI (Body Mass Index) \\\u003C27 kg\u002Fm2 without diabetes defined by a blood glucose ≤ 6 mmol\u002FL and \u002F or ≤ 7.8 mmol\u002Fl, 120 minutes after ingestion of glucose (oral glucose tolerance test)",{"label":22,"type":10,"description":20,"interventionNames":10},"27 \u003C BMI \u003C 35 kg\u002Fm2 without diabetes",[24],{"name":25,"affiliation":5,"role":26},"Francois PATTOU, MD PhD","PRINCIPAL_INVESTIGATOR",[28,31],{"name":25,"role":29,"phone":10,"phoneExt":10,"email":30},"CONTACT","fpattou@univ-lille2.fr",{"name":32,"role":29,"phone":10,"phoneExt":10,"email":33},"Violeta Raverdy, MD","vraverdi@univ-lille2.fr",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":10,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Lille University Hospital","RECRUITING","Lille","Nord","France",{"type":42,"coordinates":43},"Point",[44,45],3.05512,50.63391,{"lat":45,"lon":44},[48],{"name":49,"role":29,"phone":10,"phoneExt":10,"email":10},"François PATTOU, MD, PhD",{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100142762",false,"NCT01129297","A Biological Atlas of Severe Obesity (Biological Tissue Collection)","Influence of the Glycemic and Ponderal Status on Tissues Gene Expression (Biological Tissue Collection)","ABOS","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Indication of abdominal surgery requiring a laparotomy or laparoscopy for bariatric surgery, cholecystectomy, or parietal surgical\n* Phenotype corresponding to one of the following four cases :\n\n  1. Body Mass Index ≥ 35 kg\u002Fm2 and diabetes defined by a fasting blood glucose ≥ 7 mmol\u002Fl and\u002For ≥ to 11.1 mmol\u002Fl, 120 minutes after ingestion of glucose (hyperglycemia caused by oral route)\n  2. Body Mass Index ≥ 35 kg\u002Fm2 with intolerance glucose defined by a fasting blood glucose\\> 6 mmol\u002FL and \\\u003C7 mmol\u002Fl and\u002For\\> 7.8 mmol\u002Fl and \\\u003C11.1 mmol\u002Fl , 120 minutes after ingestion of glucose (hyperglycemia caused by oral route)\n  3. Body Mass Index ≥ 35 kg\u002Fm2 without diabetes defined by a blood glucose ≤ 6 mmol\u002FL and \u002F or ≤ 7.8 mmol\u002Fl, 120 minutes after ingestion of glucose (hyperglycemia caused by oral route)\n  4. Body Mass Index \\\u003C27 kg\u002Fm2 without diabetes defined by a blood glucose ≤ 6 mmol\u002FL and \u002F or ≤ 7.8 mmol\u002Fl, 120 minutes after ingestion of glucose (hyperglycemia caused by oral route)\n\n5)27 \\\u003CBody Mass Index \\\u003C35 kg\u002Fm2 without diabetes defined by a blood glucose ≤ 6 mmol\u002FL and \u002F or ≤ 7.8 mmol\u002Fl, 120 minutes after ingestion of glucose (hyperglycemia caused by oral route)\n\nExclusion Criteria:\n\n* unable to receive clear information\n* refusal to sign the consent form\n* pathology associated judged by the surgeon, may increase the risk of adverse events related to sampling tissue",true,"ALL","18 Years","65 Years",{"count":64,"type":65},20000,"ESTIMATED","OBSERVATIONAL","Type 2 diabetes and obesity are both multifactorial diseases resulting from gene-environment interactions. However, this interaction, as well as the specific effect of each polymorphism, remains poorly understood.\n\nWe now proposed a prospective cohort study to improve our understanding of the influence of phenotypic characteristics on gene expression in tissues involved in glucose and\u002For lipid metabolism by collecting different biological samples.",[69,70,71],"Obesity","Glucose Intolerance","Diabetes",[69,73,74,75],"surgery","genetic expression","collection of samples","2025-12-02",{"date":78,"type":79},"2025-12-08","ACTUAL",{"date":81,"type":79},"2006-06-13",{"date":83,"type":65},"2027-06",{"name":5,"class":6},1]