[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567855":3},{"organization":4,"outcomesModule":7,"designInfo":40,"detailedDescription":43,"studyPopulation":44,"armGroups":45,"interventions":39,"overallOfficials":39,"centralContacts":49,"locations":55,"responsibleParty":73,"collaborators":75,"id":79,"slug":39,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":39,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":39,"enrollmentInfo":88,"targetDuration":39,"studyType":91,"phases":39,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":57,"whyStopped":39,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Shanghai East Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":39},[9],{"measure":10,"description":11,"timeFrame":12},"All-cause mortality rate","All-cause mortality rate of different stages of heart failure","10 years",[14,17,21,24,27,30,33,36],{"measure":15,"description":16,"timeFrame":12},"Prevalence of early heart failure","The prevalence of early heart failure was defined as morbidity of stage A heart failure and stage B heart failure. Stage A HF was defined as at risk for HF but without current or previous symptoms\u002Fsigns of HF and without structural\u002Ffunctional heart disease or abnormal biomarkers.(eg. patients with hypertension, coronary artery disease, diabetes, obesity, atrial fibrillation\u002Fatrial flutter or tumour). Stage B HF was defined as no symptoms or signs of HF and evidence of one of the following:1) EF value\\\u003C52 in male and \\\u003C54 in female. 2) Increased NT-proBNP levels (≥125 pg\u002Fml) or elevated TnT levels (\\>0.017ng\u002Fml).",{"measure":18,"description":19,"timeFrame":20},"Progress of heart failure of Stage A","The morbidity rate of stage B heart failure, stage C heart failure and stage D heart failure in stage A heart failure patients in 2 year, 6 years and 10 years. Stage A HF was defined as at risk for HF but without current or previous symptoms\u002Fsigns of HF and without structural\u002Ffunctional heart disease or abnormal biomarkers.(eg. patients with hypertension, coronary artery disease, diabetes, obesity, atrial fibrillation\u002Fatrial flutter or tumour). Stage B HF was defined as no symptoms or signs of HF and evidence of one of the following:1)EF value\\\u003C52 in male and \\\u003C54 in female.2) Increased NT-proBNP levels (≥125 pg\u002Fml) or elevated TnT levels (\\>0.017ng\u002Fml). Stage C\u002FD HF was defined as previous history of HF or structural heart disease with current or previous symptoms of HF (eg. dyspnea, swelling of both lower extremities), diagnosed by two cardiac specialists.","Following up 10 years",{"measure":22,"description":23,"timeFrame":20},"Progress of heart failure of Stage B","The morbidity rate of stage C heart failure and stage D heart failure in stage B heart failure patients in 2 year, 6 years and 10 years. Stage B HF was defined as no symptoms or signs of HF and evidence of one of the following:1)EF value\\\u003C52 in male and \\\u003C54 in female.2) Increased NT-proBNP levels (≥125 pg\u002Fml) or elevated TnT levels (\\>0.017ng\u002Fml). Stage C\u002FD HF was defined as previous history of HF or structural heart disease with current or previous symptoms of HF (eg. dyspnea, swelling of both lower extremities), diagnosed by two cardiac specialists.",{"measure":25,"description":26,"timeFrame":20},"Progress of heart failure of Stage C","The morbidity rate of stage D heart failure in stage C heart failure patients in 2 year, 6 years and 10 years. Stage C HF was defined as previous history of HF or structural heart disease with current or previous symptoms of HF (eg. dyspnea, swelling of both lower extremities). Stage D HF was defined as Marked HF symptoms that interfere with daily life and with recurrent hospitalizations despite attempts to optimize GDMT.",{"measure":28,"description":29,"timeFrame":20},"Clinical endpoints of heart failure","Time of first occurrence of symptomatic heart failure. Symptomatic heart failure was defined as current or previous symptoms\u002Fsigns of HF.",{"measure":31,"description":32,"timeFrame":20},"New cardiovascular events","Incidence rate of cardiovascular events",{"measure":34,"description":35,"timeFrame":12},"Referral rate","Proportion of patients referred to higher-level hospitals due to heart failure",{"measure":37,"description":38,"timeFrame":12},"Cardiovascular mortality rate","Cardiovascular mortality rate of different stages of heart failure",null,{"allocation":39,"interventionModel":39,"interventionModelDescription":39,"primaryPurpose":39,"observationalModel":41,"timePerspective":42,"maskingInfo":39},"COHORT","PROSPECTIVE","Heart failure is a serious manifestation or advanced stage of various heart diseases with high mortality and re-hospitalization rates, and early diagnosis of heart failure is important to improve patient survival. Currently, the prevalence of preclinical heart failure (heart failure stage B) is lacking in China, and the rate of progression of heart failure from stage A\u002FB to symptomatic heart failure (heart failure stage C) and end-stage heart failure (heart failure stage D) and the factors influencing the heart failure development are unknown.\n\nThe study is an ongoing prospective community-based study. After enrollment, a questionnaire, physical examination, laboratory examination and imaging examination will be administered to each participant at baseline and every 2 years in the follow-up. The laboratory and imaging examination include: blood\u002Furine sample and biochemical measurements, electrocardiogram, echocardiograph, etc. In the follow-up, the incidence of cardiovascular disease, heart failure, other CV events and mortality will be recorded. Whether at baseline or follow-up, if the investigators find that patients are unclear about their disease status, the investigators will notify them by phone and record their subsequent medical behavior and results.\n\nIn this study, a community-based database and biobank will be established for early screening and long-term prognosis of heart failure in elderly population. Through the analysis of the data, the epidemiological characteristics of early stage of heart failure in elderly population in Shanghai can be identified and a multivariable model predicting heart failure in early stage will be constructed. Furtherly，the investigators will explore the referral criteria and hierarchical management strategies for heart failure through the cooperation between community hospitals and comprehensive hospitals.","Elderly people who have signed informed consent forms for physical examinations in Beicai Community",[46],{"label":47,"type":39,"description":48,"interventionNames":39},"Stages of Heart Failure in a Community-based Cohort China","A community-based cohort on stage A (at risk for HF), stage B (pre-HF) or stage C (symptomatic HF) of heart failure in China elderly people",[50],{"name":51,"role":52,"phone":53,"phoneExt":39,"email":54},"Wei Han, Doctor","CONTACT","+86-021-38804518","dr.hanwei@foxmail.com",[56],{"facility":5,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"RECRUITING","Shanghai","Shanghai Municipality","200120","China","CN",{"type":64,"coordinates":65},"Point",[66,67],121.45806,31.22222,{"lat":67,"lon":66},[70],{"name":71,"role":52,"phone":53,"phoneExt":39,"email":72},"Xin Gon, Doctor","412900471@qq.com",{"type":74,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR",[76],{"name":77,"class":78},"Beicai Community Health Service Center of Pudong District, Shanghai, China","UNKNOWN","100567855",false,"NCT06673615","A Cohort Study on Early Stages of Heart Failure","A Community-based Cohort Study on Early Screening of Heart Failure in Elderly Population in Shanghai","Inclusion Criteria:\n\n1. Age ≥60 years\n2. Cooperate in participating in research and sign informed consent forms\n\nExclusion Criteria:\n\n1. End stage heart failure patients\n2. Refusal to participate in this study\n3. Patients who are not suitable to participate in this study by Researchers\\'s evaluation",true,"ALL","60 Years",{"count":89,"type":90},8000,"ESTIMATED","OBSERVATIONAL","The main goal of this observational study is to learn about the epidemiological characteristics of heart failure among elder population in Beicai community in Shanghai and construct a community-based database and biobank. The main question it aims to answer is:\n\nWhat is the prevalence and prognosis of different stages of heart failure among elder population in community in Shanghai? And what are the influencing factors? What are the best screening strategies and hierarchical management strategies among different stages of heart failure patients in community? Participants are the elderly people aged 60 years or older in Beicai community in China. The follow-up will be programmed every 2 years.",[94],"Stages of Heart Failure",[96,97,98,99],"Heart failure","Early screening","Elderly population","Epidemiology","2024-11-02",{"date":102,"type":103},"2024-11-05","ACTUAL",{"date":105,"type":103},"2024-04-15",{"date":107,"type":90},"2044-08-30",{"name":5,"class":6},1]