[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616946":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":14,"centralContacts":18,"locations":27,"responsibleParty":52,"collaborators":10,"id":54,"slug":10,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy pregnant women residing at high altitude",null,"Women with uncomplicated pregnancy.",{"label":13,"type":10,"description":11,"interventionNames":10},"Healthy pregnant women residing at sea level",[15],{"name":16,"affiliation":5,"role":17},"Lorenzo Berra, MD","PRINCIPAL_INVESTIGATOR",[19,23],{"name":16,"role":20,"phone":21,"phoneExt":10,"email":22},"CONTACT","617-726-3030","lberra@mgh.harvard.edu",{"name":24,"role":20,"phone":25,"phoneExt":10,"email":26},"Andrea Bolchini, MD","617-216-5124","abolchini@mgh.harvard.edu",[28,42],{"facility":5,"status":29,"city":30,"state":31,"zip":32,"country":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Boston","Massachusetts","02114","United States",{"type":35,"coordinates":36},"Point",[37,38],-71.05977,42.35843,{"lat":38,"lon":37},[41],{"name":16,"role":20,"phone":10,"phoneExt":10,"email":10},{"facility":43,"status":44,"city":45,"state":10,"zip":10,"country":46,"cosmosGeoPoint":47,"geoPoint":51,"contacts":10},"Hospital De La Meujer","COMPLETED","La Paz","Bolivia",{"type":35,"coordinates":48},[49,50],-68.15,-16.5,{"lat":50,"lon":49},{"type":17,"investigatorFullName":16,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PI","100616946",false,"NCT07312227","A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia","Inclusion Criteria:\n\n* women delivering at participating hospitals at more than 3500 meters or women delivering at participating hospitals at sea level\n* signed informed consent\n\nExclusion Criteria:\n\n* preexisting cardiopulmonary pathologies (CHD, COPD, CKD, NYHA \\> III)",true,"FEMALE","18 Years","45 Years",{"count":64,"type":65},27,"ESTIMATED","OBSERVATIONAL","In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \\>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.",[69,70,71],"Hypertensive Disorder of Pregnancy","Pulmonary Arterial Hypertension","Intrauterine Growth Restriction","2026-05-21",{"date":74,"type":75},"2026-05-26","ACTUAL",{"date":77,"type":75},"2026-02-11",{"date":79,"type":65},"2027-02",{"name":5,"class":6},2]