[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589405":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":36,"centralContacts":41,"locations":52,"responsibleParty":73,"collaborators":69,"id":77,"slug":69,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":69,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":69,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":69,"overallStatus":55,"whyStopped":69,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Asian Institute of Gastroenterology, India","OTHER",[8,13,17],{"label":9,"type":6,"description":10,"interventionNames":11},"To determine whether Vonaprazon 10mg heals grade B esophagitis at 8 weeks","Vonaprazon 10 mg heals gerd symptoms after 8 weeks",[12],"Drug: Vonoprazan",{"label":14,"type":6,"description":15,"interventionNames":16},"To determine whether Vonaprazon 20mg heals grade B esophagitis at 8 weeks","Vonaprazon 20 mg heals gerd symptoms after 8 weeks",[12],{"label":18,"type":6,"description":19,"interventionNames":20},"To determine whether esomeprazole 40mg heals grade B esophagitis at 8 weeks","Esomeprazole 40mg heals gerd symptoms after 8 weeks",[21],"Drug: Esomeprazole 40mg",[23,30],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Vonoprazan","Vonaprazon is potassium competitive acid blockers",[9,14],[29],"PCAB",{"type":24,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Esomeprazole 40mg","esomeprazole is a proton pump inhibitor as it prevents excess of gastric acid secretion in the stomach",[18],[35],"Proton pump inhibitor",[37],{"name":38,"affiliation":39,"role":40},"Mohan Dr Ramchandani, MD DM","Asian Institute of Gastroenterology","STUDY_DIRECTOR",[42,48],{"name":43,"role":44,"phone":45,"phoneExt":46,"email":47},"Rajesh Goud Mr Maragoni, M.Pharm","CONTACT","04023378888","410","rajeshgoud761@gmail.com",{"name":49,"role":44,"phone":45,"phoneExt":50,"email":51},"Zaheer Dr Nabi, MD DNB","503","zaheernabi1978@gmail.com",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Asian Institute of Gastroenterology \u002FAig Hospitals","RECRUITING","Hyderabad","Telangana","500082","India",{"type":61,"coordinates":62},"Point",[63,64],78.45636,17.38405,{"lat":64,"lon":63},[67,70],{"name":68,"role":44,"phone":45,"phoneExt":69,"email":51},"ZAHEER DR NABI, MBBS MDDNB",null,{"name":71,"role":44,"phone":45,"phoneExt":72,"email":47},"Rajesh Goud Mr Maragoni, M.Pharm MBA","301",{"type":74,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":69,"oldOrganization":69},"PRINCIPAL_INVESTIGATOR","Mohan Ramchandani","Director","100589405",false,"NCT06953986","A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks","Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks","Inclusion Criteria:\n\n* Adults ≥18 years of age.\n* Endoscopically confirmed LA grade B, C, or D reflux esophagitis.\n* GERD symptoms (heartburn, regurgitation) for at least 4 weeks prior to enrollment.\n* Willing to provide informed consent and comply with study procedures.\n\nExclusion Criteria:\n\n* Previous or ongoing treatment with Vonaprazan or Esomeprazole in the last 4 weeks.\n* Prior esophageal surgery or radiation therapy.\n* Barrett's esophagus, esophageal stricture, or malignancy.\n* Pregnant or breastfeeding women.\n* History of PPI-refractory GERD or severe gastroparesis.\n* Significant hepatic or renal impairment (ALT\u002FAST \\>3× ULN, eGFR \\\u003C30 mL\u002Fmin).\n* Use of NSAIDs, steroids, or anticoagulants affecting healing.","ALL","18 Years","75 Years",{"count":87,"type":88},414,"ESTIMATED","INTERVENTIONAL",[91],"NA","Primary Objective\n\n• To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks among patients treated with Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg once daily.\n\nSecondary Objectives\n\n* To assess the improvement in reflux symptoms using the GERD-Q score at 8 weeks.\n* To evaluate the incidence of adverse events across treatment groups.",[94],"GERD","2026-03-04",{"date":97,"type":98},"2026-03-06","ACTUAL",{"date":100,"type":98},"2025-12-20",{"date":102,"type":88},"2027-12-12",{"name":5,"class":6},1]