[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100363472":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":32,"overallOfficials":13,"centralContacts":36,"locations":46,"responsibleParty":68,"collaborators":13,"id":72,"slug":13,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":13,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":13,"maxAge":13,"enrollmentInfo":79,"targetDuration":13,"studyType":82,"phases":13,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":48,"whyStopped":13,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"First Affiliated Hospital of Fujian Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"The change of Unified Wilson's Disease Rating Scale (UWDRS)","Disease severity will be assessed by application of the Unified Wilson's Disease Rating Scale (UWDRS), a clinical rating scale consists of three subscales. Higher UWDRS total scores indicate more severe disease.","Up to 30years",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Patients with Wilson's Disease are diagnosed by the clinical and\u002For genetic features",[19,23,26,29],{"label":20,"type":13,"description":13,"interventionNames":21},"Patients with the genetic diagnosis of Wilson's Disease",[22],"Other: No intervention",{"label":24,"type":13,"description":13,"interventionNames":25},"Asymptomatic Wilson's Disease carriers",[22],{"label":27,"type":13,"description":13,"interventionNames":28},"Relatives of Wilson's Disease patients or carriers",[22],{"label":30,"type":13,"description":13,"interventionNames":31},"Unrelated healthy controls",[22],[33],{"type":6,"name":34,"description":34,"armGroupLabels":35,"otherNames":13},"No intervention",[24,20,27,30],[37,42],{"name":38,"role":39,"phone":40,"phoneExt":13,"email":41},"Jin He, MD","CONTACT","86-0591-87982772","hejinfjmu@hotmail.com",{"name":43,"role":39,"phone":44,"phoneExt":13,"email":45},"Yi Lin, MD.PhD","8613615039153","linyi7811@163.com",[47],{"facility":5,"status":48,"city":49,"state":13,"zip":13,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Fuzhou","China","CN",{"type":53,"coordinates":54},"Point",[55,56],119.30611,26.06139,{"lat":56,"lon":55},[59,61,62,65],{"name":38,"role":39,"phone":13,"phoneExt":60,"email":13},"+1386061359",{"name":13,"role":39,"phone":40,"phoneExt":13,"email":41},{"name":63,"role":64,"phone":13,"phoneExt":13,"email":13},"Wan-Jin Chen, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":66,"role":67,"phone":13,"phoneExt":13,"email":13},"Ning Wanf, MD,PhD","SUB_INVESTIGATOR",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"SPONSOR_INVESTIGATOR","Wan-Jin Chen","The Vice-Director for the Department of Neurology","100363472",false,"NCT04012658","A Registered Cohort Study on Wilson's Disease","Inclusion Criteria:\n\n* Patients with the genetic diagnosis of Wilson's Disease\n* Asymptomatic Wilson's Disease carriers\n* Relatives of Wilson's Disease patients or carriers\n* Unrelated healthy controls\n* Participants or Parent(s)\u002Flegal guardian(s) willing and able to complete the informed consent process\n\nExclusion Criteria:\n\n\\* Participants are unable to comply with study procedures and visit schedule",true,"ALL",{"count":80,"type":81},2000,"ESTIMATED","OBSERVATIONAL","The aim of this study is to determine the clinical spectrum and natural progression of Wilson's Disease in a prospective multicenter natural history study, to assess the clinical, genetic, epigenetic features and biomarkers of patients with Wilson's Disease to optimize clinical management.",[85],"Wilson's Disease",[85,87,88],"Nature history","Genetics","2019-09-19",{"date":91,"type":92},"2019-09-23","ACTUAL",{"date":94,"type":92},"2019-07-01",{"date":96,"type":81},"2049-12",{"name":70,"class":6},1]