[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630165":3},{"organization":4,"outcomesModule":7,"designInfo":27,"detailedDescription":11,"studyPopulation":30,"armGroups":31,"interventions":11,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":34,"collaborators":11,"id":38,"slug":11,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":11,"eligibilityCriteria":42,"healthyVolunteers":39,"sex":43,"minAge":44,"maxAge":11,"enrollmentInfo":45,"targetDuration":11,"studyType":48,"phases":11,"briefSummary":49,"conditions":50,"keywords":11,"overallStatus":52,"whyStopped":11,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":11},{"fullName":5,"class":6},"Southeast University, China","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"ICU mortality",null,"up to 24 months",[14,16,18,20,22,24],{"measure":15,"description":11,"timeFrame":12},"Hospital mortality",{"measure":17,"description":11,"timeFrame":12},"Length of mechanical ventilation",{"measure":19,"description":11,"timeFrame":12},"Length of ICU stay",{"measure":21,"description":11,"timeFrame":12},"Length of hospital Stay",{"measure":23,"description":11,"timeFrame":12},"Incidence of hospital- acquired infections",{"measure":25,"description":26,"timeFrame":12},"Incidence of gastrointestinal intolerance","During enteral nutrition support in ICU",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":28,"timePerspective":29,"maskingInfo":11},"COHORT","RETROSPECTIVE","Patients admitted to the ICU",[32],{"label":33,"type":11,"description":11,"interventionNames":11},"Patients in the ICU received mechanical ventilation",{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Ling Liu","Professor","100630165",false,"NCT07484126","A Retrospective Clinical Study of Metabolic Status and Response to Nutritional Therapy in Patients With Mechanical Ventilation","Inclusion Criteria:\n\n* age ≥18 years old;\n* ICU admission ≥72 hours with invasive mechanical ventilation ≥24 hours;\n* start nutrition therapy within 72 hours after ICU admission and receive enteral or parenteral nutrition support for ≥3 days;\n* Relatively complete nutritional intervention records and nutrition-related biomarkers test results on the 1st, 3rd, and 7th (±1) days of ICU admission;\n\nExclusion Criteria:\n\n* women of childbearing age who have a positive pregnancy test, are pregnant or lactating;\n* chronic diseases with serious organ function damage or serious complications;\n\n  1. Kidney: chronic kidney disease stage 4 or 5;\n  2. Liver: previous history of liver failure, hepatic encephalopathy, or hepatic coma, gastrointestinal bleeding due to portal hypertension or Child-Pugh score ≥10 in recent years;\n* advanced malignant tumor, or chemotherapy or immunotherapy received within one month before admission;\n* severe immunodeficiency or current use of potent immunosuppressive agents, agranulocytosis (N\\\u003C0.5×10\\^9\u002FL), active hematologic malignancies or HIV stage III infection; Patients who were treated with immune-inducing drugs, such as antithymocyte globulin (ATG), antilymphocyte globulin (ALG), interleukin-2 receptor a chain antibody (IL-2RA), interleukin-6 receptor A antibody (IL-6RA); glucocorticoid therapy was continued for nearly 2 weeks, with a daily dose exceeding the hydrocortisone equivalent of 200mg;\n* critical illness, death in ICU within 1 week or palliative care only because death outcome was inevitable;\n* combined with severe or more severe burns: more than 30% of total body surface area burned or more than 10% of third-degree burn area; Or the total area is less than 30%, but the whole body condition is severe, or there are shock, combined injury, and respiratory tract burn.","ALL","18 Years",{"count":46,"type":47},2000,"ESTIMATED","OBSERVATIONAL","This study used a retrospective cohort study based on Multi-time longitudinal monitoring data were used to analyze the correlation mechanism between the dynamic evolution characteristics of nutrition-related biochemical indicators and individualized nutritional intervention in patients with mechanical ventilation. The inflammation-nutrition interaction model was constructed to correct the interference effect of inflammatory microenvironment on nutritional status assessment, so as to provide a basis for further achieving precision nutritional support.",[51],"Mechanical Ventilation","NOT_YET_RECRUITING","2026-03-17",{"date":55,"type":56},"2026-03-19","ACTUAL",{"date":58,"type":47},"2026-04",{"date":60,"type":47},"2026-08",{"name":5,"class":6}]