[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566948":3},{"organization":4,"outcomesModule":7,"designInfo":16,"detailedDescription":22,"studyPopulation":11,"armGroups":23,"interventions":29,"overallOfficials":35,"centralContacts":40,"locations":45,"responsibleParty":59,"collaborators":11,"id":61,"slug":11,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":11,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":11,"studyType":73,"phases":74,"briefSummary":75,"conditions":76,"keywords":11,"overallStatus":78,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Beijing Boren Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9,13],{"measure":10,"description":11,"timeFrame":12},"Dose Limiting Toxicity",null,"0~28 day after treatment",{"measure":14,"description":11,"timeFrame":15},"Frequency of AEs, SAEs","0 day to 24 months after treatment",{"allocation":17,"interventionModel":18,"interventionModelDescription":11,"primaryPurpose":19,"observationalModel":11,"timePerspective":11,"maskingInfo":20},"NA","SINGLE_GROUP","TREATMENT",{"masking":21,"maskingDescription":11,"whoMasked":11},"NONE","Autoimmune disease refers to the disease in which the immune system reacts to the host's own body and causes damage to tissues and organs.\n\nAutoreactive B cells can self-activate and differentiate into plasma cells releasing large amounts of autoantibodies, while they can also present their own antigens to autoimmune T cells, thus activating T cells and promoting the release of inflammatory factors.\n\nCAR-T cells can theoretically completely deplete abnormal antibody-producing B cells, allowing immune rebuilding and restoring the patient's normal immune function, achieving drug-free survival, which fully reflects the application prospects of CAR-T therapy in autoimmune disease.",[24],{"label":25,"type":26,"description":11,"interventionNames":27},"CAR-T treatment","EXPERIMENTAL",[28],"Drug: CAR-T",[30],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":11},"DRUG","CAR-T","CAR-T cells",[25],[36],{"name":37,"affiliation":38,"role":39},"Yajing Zhang, MD\u002FPhD","Beijing Gaobo Boren Hospital","PRINCIPAL_INVESTIGATOR",[41],{"name":37,"role":42,"phone":43,"phoneExt":11,"email":44},"CONTACT","+8601083605002（716）","z18501333856@126.com",[46],{"facility":38,"status":11,"city":47,"state":11,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Beijing","100070","China","CN",{"type":52,"coordinates":53},"Point",[54,55],116.39723,39.9075,{"lat":55,"lon":54},[58],{"name":37,"role":42,"phone":43,"phoneExt":11,"email":44},{"type":60,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100566948",false,"NCT06661811","A Study of CAR-T Cells Targeting Autoimmune Diseases","A Study of CAR-T Cells Targeting B Cell Related Autoimmune Diseases","Inclusion Criteria:\n\n1. Male or female, between 18 and 56 years old;\n2. Diagnosed with Autoimmune Diseases；\n3. Good organ functions;\n4. Voluntary participates this trial and can comprehend and sign ICF.\n\nExclusion Criteria:\n\n1. Had or has active malignancy;\n2. Had been subjected to treatment by CD19 targeted therapy or CAR-T therapy or any gene therapy;\n3. Combined with other autoimmune disease that needs treatment;\n4. Pregnant or lactating women;\n5. Has other factors that deemed not suitable by investigator.","ALL","18 Years","65 Years",{"count":71,"type":72},12,"ESTIMATED","INTERVENTIONAL",[17],"The purpose of this study is to assess the safety and efficacy of CAR-T cell therapy in patients with autoimmune disease.",[77],"Autoimmune Diseases","NOT_YET_RECRUITING","2024-10-25",{"date":81,"type":82},"2024-10-28","ACTUAL",{"date":84,"type":72},"2024-11-15",{"date":86,"type":72},"2028-06-20",{"name":5,"class":6},1]