[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586016":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":39,"locations":48,"responsibleParty":72,"collaborators":26,"id":75,"slug":26,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":26,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":50,"whyStopped":26,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Harokopio University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention group","EXPERIMENTAL","This arm will consume 600 mL of a sparkling beverage enriched with Chios mastic per day for a 3-month period.",[13],"Behavioral: Chios mastic beverage",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","PLACEBO_COMPARATOR","This arm will consume 600 mL of a standard sparkling beverage per day for a 3-month period.",[19],"Behavioral: Placebo beverage",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Chios mastic beverage","Participants of this intervention arm will be provided with a sparkling beverage enriched with the natural mastic aqueous extract (0.2%), a by-product of Chios mastic processing, and will be asked to consume it daily (3 bottles of 200 mL each) for 3 months. Participants will also be instructed to maintain their usual lifestyle practices and medical treatment stable.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo beverage","Participants of this intervention arm will be provided with a placebo sparkling beverage (same organoleptic characteristics with experimental beverage but no active ingredients) and will be asked to consume it daily (3 bottles of 200 mL each) for 3 months. Participants will also be instructed to maintain their usual lifestyle practices and medical treatment stable.",[15],[32,36],{"name":33,"affiliation":34,"role":35},"Giannis Arnaoutis, PhD","Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":34,"role":38},"Labros Sidossis, PhD","STUDY_DIRECTOR",[40,45],{"name":33,"role":41,"phone":42,"phoneExt":43,"email":44},"CONTACT","+302109549100","321","garn@hua.gr",{"name":46,"role":41,"phone":42,"phoneExt":43,"email":47},"Michael Georgoulis, PhD","mgeor@hua.gr",[49],{"facility":34,"status":50,"city":51,"state":52,"zip":53,"country":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Kallithea","Attica","17676","Greece",{"type":56,"coordinates":57},"Point",[58,59],23.7,37.95,{"lat":59,"lon":58},[62,63,64,65,67,68,70],{"name":33,"role":41,"phone":42,"phoneExt":43,"email":44},{"name":46,"role":41,"phone":42,"phoneExt":43,"email":47},{"name":33,"role":35,"phone":26,"phoneExt":26,"email":26},{"name":37,"role":66,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"name":46,"role":66,"phone":26,"phoneExt":26,"email":26},{"name":69,"role":66,"phone":26,"phoneExt":26,"email":26},"Alexandra Karachaliou, PhD",{"name":71,"role":66,"phone":26,"phoneExt":26,"email":26},"Evripidis Rizos, MD, PhDc",{"type":35,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"GIANNIS ARNAOUTIS","Assistant Professor","100586016",false,"NCT06909890","A Study of Chios Mastic Water in Dyspepsia","The Effectiveness of a Natural Aqueous Extract of Chios Mastic in the Management of Dyspepsia: the MASTIQUA-D Randomized Controlled Clinical Trial","MASTIQUA-D","Inclusion Criteria:\n\n* Age 30-60 years old.\n* Body mass index of 20-35 kg\u002Fm2.\n* Presence of dyspepsia.\n\nExclusion Criteria:\n\n* Presence of chronic diseases (e.g. diabetes mellitus, cancer, cardiovascular, hepatic, renal, respiratory, chronic inflammatory and psychiatric diseases).\n* Presence of other chronic gastrointestinal diseases (e.g. gastroesophageal reflux, inflammatory bowel disease and celiac disease).\n* Use of immunosuppressants, anti-inflammatories, antibiotics and corticosteroids.\n* Use of dietary supplements or other products with Chios mastic.\n* Excessive alcohol consumption (\\>210 g and \\>140 g of ethanol per week for men and women, respectively).\n* Currently on a weight-loss diet or recent (within 6 months) significant change in lifestyle habits.\n* Pregnancy or breast feeding (for women)","ALL","30 Years","60 Years",{"count":86,"type":87},60,"ESTIMATED","INTERVENTIONAL",[90],"NA","Chios mastic is a natural product with strong antimicrobial, anti-inflammatory and antioxidant properties, and well-established benefits for dyspeptic disorders. The aim of the present study is to investigate the effectiveness of a natural aqueous extract of Chios mastic (mastic water), a by-product of Chios mastic processing, in the management of dyspepsia. This will be a 3-month randomized double-blind controlled clinical trial in adults with dyspepsia. Participants will be blindly randomized to an intervention group, which will receive 600 mL\u002Fd of a carbonated beverage enriched with Chios mastic water (0.2%), or a control group, which will receive 600 mL\u002Fd of an identical placebo beverage with no active ingredients. Participants will be evaluated in terms of anthropometric indices, lifestyle habits, severity of dyspepsia-related gastrointestinal symptoms, quality of life, as well as biochemical markers, both pre- and post-intervention.",[93],"Dyspepsia",[95,96,97,98],"Pistacia Lentiscus var. Chia","Chios mastic","dyspepsia","gastrointestinal health","2025-09-09",{"date":101,"type":102},"2025-09-15","ACTUAL",{"date":104,"type":102},"2025-07-10",{"date":106,"type":87},"2026-12",{"name":5,"class":6},1]