[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589661":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":119,"collaborators":12,"id":121,"slug":12,"hasResults":122,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":12,"eligibilityCriteria":126,"healthyVolunteers":122,"sex":127,"minAge":128,"maxAge":12,"enrollmentInfo":129,"targetDuration":12,"studyType":132,"phases":133,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":40,"whyStopped":12,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":152},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Arm","NO_INTERVENTION","Participants randomized to the control group will receive tarlatamab administration as per usual care.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Hospital-at-Home\u002FHAH Intervention Arm","EXPERIMENTAL","Participants randomized to the intervention group will receive tarlatamab administration through the hospital-at-home care delivery model.",[18],"Other: Hospital-at-Home\u002FHAH",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"Hospital-at-Home\u002FHAH","After discharge, a SeniorCare community paramedic will provide a home visit to the participant's home or residence",[14],[25],{"name":26,"affiliation":5,"role":27},"Robert Daly, MD, MBA","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":32},"CONTACT","646-608-3789","dalyr1@mskcc.org",{"name":34,"role":30,"phone":35,"phoneExt":12,"email":36},"Michael Offin, MD","646-608-3763","offinm@mskcc.org",[38,53,64,75,87,98,108],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)","RECRUITING","Basking Ridge","New Jersey","07920","United States",{"type":46,"coordinates":47},"Point",[48,49],-74.54932,40.70621,{"lat":49,"lon":48},[52],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":12},{"facility":54,"status":40,"city":55,"state":42,"zip":56,"country":44,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Memorial Sloan Kettering Monmouth (Limited Protocol Activities)","Middletown","07748",{"type":46,"coordinates":58},[59,60],-74.11709,40.39428,{"lat":60,"lon":59},[63],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":12},{"facility":65,"status":40,"city":66,"state":42,"zip":67,"country":44,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Memorial Sloan Kettering Bergen (Limited Protocol Activities)","Montvale","07645",{"type":46,"coordinates":69},[70,71],-74.02292,41.04676,{"lat":71,"lon":70},[74],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":12},{"facility":76,"status":40,"city":77,"state":78,"zip":79,"country":44,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities)","Commack","New York","11725",{"type":46,"coordinates":81},[82,83],-73.29289,40.84288,{"lat":83,"lon":82},[86],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":12},{"facility":88,"status":40,"city":89,"state":78,"zip":90,"country":44,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Memorial Sloan Kettering Westchester (Limited Protocol Activities)","Harrison","10604",{"type":46,"coordinates":92},[93,94],-73.71263,40.96899,{"lat":94,"lon":93},[97],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":12},{"facility":99,"status":40,"city":78,"state":78,"zip":100,"country":44,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Memorial Sloan Kettering Cancer Center (All Protocol Activites)","10065",{"type":46,"coordinates":102},[103,104],-74.00597,40.71427,{"lat":104,"lon":103},[107],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":12},{"facility":109,"status":40,"city":110,"state":78,"zip":111,"country":44,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Memorial Sloan Kettering Nassau (Limited Protocol Activities)","Uniondale","11553",{"type":46,"coordinates":113},[114,115],-73.59291,40.70038,{"lat":115,"lon":114},[118],{"name":26,"role":30,"phone":31,"phoneExt":12,"email":12},{"type":120,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100589661",false,"NCT06957314","A Study of Hospital-at-Home for People Receiving Tarlatamab","MATCHES-Novel: MAking Telehealth Delivery of Cancer Care at Home Effective and Safe for Novel Therapies: A Hospital-at-Home Model for Tarlatamab Delivery","Inclusion Criteria:\n\nPatient\n\n* Diagnosis of extensive stage small cell lung carcinoma (ES-SCLC)\n* Treatment plan of commercially available tarlatamab monotherapy as standard of care\n* Patients must be 18 years of age or older\n* Eastern Cooperative Oncology Group (ECOG) performance status \\\u003C2\n* Patients must have adequate organ and bone marrow function, defined by the following laboratory results obtained within 28 days prior to the first study treatment:\n\n  * ANC ≥ 1000 cells\u002FμL (without granulocyte colony stimulating factor support within 4 weeks prior to Cycle 1, Day 1)\n  * Platelet count ≥50,000\u002FμL (without transfusion within 4 weeks prior to Cycle 1, Day 1)\n  * Hemoglobin ≥8.0 g\u002FdL (without transfusion within 4 weeks prior to Cycle 1, Day 1)\n  * Alanine aminotransferase (ALT), aspartate aminotransferase (AST) ≤ 3 X upper limit of normal (ULN). Serum bilirubin ≤ 1.5 x ULN. Patients with known Gilbert disease who have serum bilirubin level ≤ 2 x ULN may be enrolled.\n  * Estimated Glomerular Filtration Rate (eGFR) ≥ 30mL\u002Fmin using the CKD-EPI formula.\n* The patient is willing to give and sign informed consent\n* Appropriate homebound setting as defined by one of the following:\n\n  * Lodging at MSK Residence or hotel\n  * 5 New York City boroughs, lower Westchester County (northern boundary Cross County Parkway) and Nassau County (eastern boundary Wantagh State Parkway). This is based on the community paramedic (SeniorCare) 60-minute response time catchment area. If there is any uncertainty about patient residence eligibility, the Principal Investigator will decide after discussion with SeniorCare.\n* Patients must be accompanied by a caregiver for the period of time the patient is enrolled in the HaH intervention. For cases where there is uncertainty, the Principal Investigator will make the final determination.\n\nCaregiver\n\n* Primary caregiver as identified by patient enrolled on study\n\nPhysician\n\n* Treating physician for patient(s) enrolled on study; managing treatment plan of commercially available tarlatamab as standard of care\n\nExclusion Criteria:\n\nPatient\n\n* Patients with a documented active infection prior to starting tarlatamab. This includes grade 3 or higher viral, bacterial, or fungal infection.\n* Patients with baseline dementia or cognitive barriers\n* Uncontrolled arrhythmias\n\nCaregiver\n\n* Caregiver deemed inappropriate by treating physician\n\nPhysician\n\n* No exclusion criteria","ALL","18 Years",{"count":130,"type":131},70,"ESTIMATED","INTERVENTIONAL",[134],"NA","The purpose of this study is to find out whether a Hospital-at-Home (HaH) program is a more efficient way to monitor people's health after receiving tarlatamab than monitoring in the hospital (inpatient).",[137,138],"Small-cell Lung Cancer","Small Cell Lung Carcinoma",[137,138,140,5,141,142],"Tarlatamab","25-077","extensive stage small cell lung cancer","2026-06-11",{"date":145,"type":146},"2026-06-12","ACTUAL",{"date":148,"type":146},"2025-04-23",{"date":150,"type":131},"2028-04-23",{"name":5,"class":6},7]