[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500231":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":53,"collaborators":10,"id":56,"slug":10,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":10,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"T2MI Patients",null,"Patients with T2MI and no epicardial coronary stenosis \\>50% will be prospectively enrolled and undergo a routine standard of care coronary angiogram with coronary reactivity testing (CRT).",[13],"Diagnostic Test: Coronary angiogram with coronary reactivity testing (CRT)",{"label":15,"type":10,"description":16,"interventionNames":10},"Controls","Patients with atypical chest pain and no obstructive disease on coronary angiogram who have been referred for investigation of suspected CMD and have a clinical indication for CMD testing will be retrospectively enrolled and data collected from a previous routine standard of care coronary angiogram with coronary reactivity testing (CRT) will be utilized.",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","Coronary angiogram with coronary reactivity testing (CRT)","CRT is an angiography procedure (using X-ray) to examine the small blood vessels in the heart and how they respond to three drugs (adenosine, acetylcholine and nitroglycerin) as per clinical protocol.",[9],[24],{"name":25,"affiliation":5,"role":26},"Claire Raphael, MBBS, PhD.","PRINCIPAL_INVESTIGATOR",[28,32],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":10},"Ischemic Heart Disease Research Team","CONTACT","507-255-1724",{"name":33,"role":30,"phone":34,"phoneExt":10,"email":35},"Claire Raphael, MBBS, PhD","507-255-2445","Raphael.Claire@mayo.edu",[37],{"facility":38,"status":10,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Mayo Clinic Rochester","Rochester","Minnesota","55905","United States",{"type":44,"coordinates":45},"Point",[46,47],-92.4699,44.02163,{"lat":47,"lon":46},[50,51,52],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":10},{"name":33,"role":30,"phone":34,"phoneExt":10,"email":35},{"name":33,"role":26,"phone":10,"phoneExt":10,"email":10},{"type":26,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Claire E. Raphael","Principal Investigator","100500231",false,"NCT05793567","A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)","Assessment of Microcirculatory Function in Type 2 Myocardial Infarction","Inclusion Criteria:\n\n* Ability to give informed consent\n* Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease)\n* For controls: atypical chest pain with indication for CMD testing\n* For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise\u002Ffall of troponin with at least 1 value \\>99th centile+ evidence of symptoms or signs of myocardial ischemia)\n\nExclusion Criteria:\n\n* Acute coronary event (evidence of plaque rupture, fissure or dissection on coronary angiogram)\n* Known to have angiographically significant CAD\u002Fpressure wire positive for epicardial CAD\n* Inability to receive heparin products\n* Allergy\u002Fcontraindication to acetylcholine\u002Fadenosine\u002Fnitroglycerine products\n* Prior coronary artery bypass grafting\n* Pregnancy (if sexually active woman of reproductive age, need negative pregnancy test prior to proceeding with coronary angiography - this is standard of care in cath lab)\n* Asthma with prior ICU admission due to bronchospasm\u002Fneed for invasive ventilation","ALL","18 Years",{"count":65,"type":66},52,"ESTIMATED","OBSERVATIONAL","The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).",[70,71],"Myocardial Infarction","Coronary Microvascular Disease","NOT_YET_RECRUITING","2025-08-21",{"date":75,"type":76},"2025-08-28","ACTUAL",{"date":78,"type":66},"2026-08",{"date":80,"type":66},"2027-04",{"name":5,"class":6},1]