About this trial

To evaluate the efficacy and safety of iNK cells infusion in patients with chronic active Epstein-Barr virus infection (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)

Eligibility criteria

Qualifiers

≤65 years,ECOG :0-2;

Cardiac EF≥40%, creatinine clearance ≥50%; aminotransferase(ALT/AST)<200U/L。;

In patients with HLH, HLH efficacy ≥Partial Response after prior treatment is required;

Estimated survival time is longer than three months;

Disqualifiers

Patients with evidence of grade II or more serious heart disease according to the New York Heart Association (NYHA) score (including Grade II) ; Clear diagnosis of cirrhosis;

Active infections other than EBV that have not yet been controlled;

Positive for hepatitis B virus or hepatitis C virus;

Active massive hemorrhage of internal organs (including gastrointestinal hemorrhage, alveolar hemorrhage, intracranial hemorrhage, etc.);

Trial design

Treatments tested in this trial

  • NCR300(Allogenic Ipsc-derived Natural Killer cells )

Treatment groups

15 Participants
are divided into 1 treatment group

Locations

1
Beijing Friendship Hospital, Capital Medical University Beijing China

Sponsors and collaborators

Beijing Friendship Hospital

Lead sponsor