[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541087":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":254,"collaborators":258,"id":266,"slug":26,"hasResults":267,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":267,"sex":273,"minAge":274,"maxAge":275,"enrollmentInfo":276,"targetDuration":26,"studyType":279,"phases":280,"briefSummary":282,"conditions":283,"keywords":287,"overallStatus":61,"whyStopped":26,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":305},{"fullName":5,"class":6},"University Children's Hospital, Zurich","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IMP arm","ACTIVE_COMPARATOR","Azithromycin Pfizer® powder for oral suspension:\n\n1 daily dose for 5 days, 10mg\u002Fkg\u002Fday on day 1 and 5mg\u002Fkg\u002Fday on days 2-5",[13],"Drug: Azithromycin Pfizer®",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo arm","PLACEBO_COMPARATOR","5 days of placebo",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Azithromycin Pfizer®","Azithromycin Pfizer® powder for oral suspension will be used in the active comparator arm: 1 daily dose for 5 days, 10mg\u002Fkg\u002Fday on day 1 and 5mg\u002Fkg\u002Fday on days 2-5",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Control comparator arm: 5 days of placebo",[15],[32],{"name":33,"affiliation":5,"role":34},"Christoph Berger, Prof. Dr. med.","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Patrick M Meyer Sauteur, PD Dr. Dr. med.","CONTACT","0041 44 266 78 96","patrick.meyersauteur@kispi.uzh.ch",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Margarete Von Wantoch, Dr. rer. nat.","0041 044 266 38 32","Margarete.VonWantoch@kispi.uzh.ch",[46,59,80,98,115,131,147,163,179,195,210,222,238],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":26},"Children's Hospital Aarau, Switzerland","ACTIVE_NOT_RECRUITING","Aarau","Canton of Aargau","5001","Switzerland",{"type":54,"coordinates":55},"Point",[56,57],8.04422,47.39254,{"lat":57,"lon":56},{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":52,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"University of Basel Children's Hospital, Switzerland","RECRUITING","Basel","Canton of Basel-City","4056",{"type":54,"coordinates":66},[67,68],7.57327,47.55839,{"lat":68,"lon":67},[71,75,77],{"name":72,"role":38,"phone":73,"phoneExt":26,"email":74},"Julia A Bielicki, PD Dr. Dr. med.","0041 61 704 12 12","julia.bielicki@ukbb.ch",{"name":72,"role":76,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"name":78,"role":79,"phone":26,"phoneExt":26,"email":26},"Ulrich Heiniger, Prof. Dr. med.","SUB_INVESTIGATOR",{"facility":81,"status":61,"city":82,"state":83,"zip":84,"country":52,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"University Children's Hospital Bern, Switzerland","Bern","Canton of Bern","3010",{"type":54,"coordinates":86},[87,88],7.44744,46.94809,{"lat":88,"lon":87},[91,95,96],{"name":92,"role":38,"phone":93,"phoneExt":26,"email":94},"Philipp Agyeman, PD Dr. med.","0041 31 632 21 11","Philipp.Agyeman@insel.ch",{"name":92,"role":76,"phone":26,"phoneExt":26,"email":26},{"name":97,"role":79,"phone":26,"phoneExt":26,"email":26},"Kristina Keitel, PD Dr. Dr. med.",{"facility":99,"status":100,"city":101,"state":102,"zip":103,"country":52,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Department of Pediatrics, Fribourg Hospital, Switzerland","NOT_YET_RECRUITING","Fribourg","Canton of Fribourg","1708",{"type":54,"coordinates":105},[106,107],7.15128,46.80237,{"lat":107,"lon":106},[110,114],{"name":111,"role":38,"phone":112,"phoneExt":26,"email":113},"Petra Zimmermann, PD Dr. Dr. med.","0041 26 306 00 00","petra.zimmermann@unifr.ch",{"name":111,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":116,"status":100,"city":117,"state":118,"zip":119,"country":52,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Children's Hospital of Geneva, University Hospitals of Geneva, Switzerland","Geneva","Canton of Geneva","1205",{"type":54,"coordinates":121},[122,123],6.14569,46.20222,{"lat":123,"lon":122},[126,130],{"name":127,"role":38,"phone":128,"phoneExt":26,"email":129},"Noémie Wagner, Dr. med.","0041 22 372 40 00","Noemie.Wagner@hcuge.ch",{"name":127,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":132,"status":61,"city":133,"state":134,"zip":135,"country":52,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"Children's Hospital of Central Switzerland, Switzerland","Lucerne","Canton of Lucerne","6000",{"type":54,"coordinates":137},[138,139],8.30635,47.05048,{"lat":139,"lon":138},[142,146],{"name":143,"role":38,"phone":144,"phoneExt":26,"email":145},"Alex Donas, Dr. med.","0041 41 205 31 66","alex.donas@luks.ch",{"name":143,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":148,"status":61,"city":149,"state":150,"zip":151,"country":52,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Children's Hospital of Eastern Switzerland St. Gallen","Sankt Gallen","Canton of St. Gallen","9006",{"type":54,"coordinates":153},[154,155],9.37477,47.42391,{"lat":155,"lon":154},[158,162],{"name":159,"role":38,"phone":160,"phoneExt":26,"email":161},"Anita Niederer-Loher, Dr. med.","0041 71 243 71 11","anita.niederer@kispisg.ch",{"name":159,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":164,"status":100,"city":165,"state":166,"zip":167,"country":52,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Department of Pediatrics, Department Mother-Woman-Child, Lausanne University Hospital, Switzerland","Lausanne","Canton of Vaud","1011",{"type":54,"coordinates":169},[170,171],6.63282,46.516,{"lat":171,"lon":170},[174,178],{"name":175,"role":38,"phone":176,"phoneExt":26,"email":177},"Ludivine Coulon, Dr. med.","0041 21 314 11 11","Ludivine.Coulon@chuv.ch",{"name":175,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":180,"status":61,"city":181,"state":182,"zip":183,"country":52,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"Department of Pediatrics, Cantonal Hospital Winterthur, Switzerland","Winterthur","Canton of Zurich","8401",{"type":54,"coordinates":185},[186,187],8.72413,47.50564,{"lat":187,"lon":186},[190,194],{"name":191,"role":38,"phone":192,"phoneExt":26,"email":193},"Andreas Jung, Dr. med.","0041 52 266 41 44","andreas.jung@ksw.ch",{"name":191,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":196,"status":61,"city":197,"state":182,"zip":198,"country":52,"cosmosGeoPoint":199,"geoPoint":203,"contacts":204},"University Children's Hospital Zurich, Switzerland","Zurich","8032",{"type":54,"coordinates":200},[201,202],8.55,47.36667,{"lat":202,"lon":201},[205,209],{"name":206,"role":38,"phone":207,"phoneExt":26,"email":208},"Michelle Seiler, PD Dr. med","0041 44 266 71 11","Michelle.Seiler@kispi.uzh.ch",{"name":206,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":211,"status":100,"city":197,"state":182,"zip":212,"country":52,"cosmosGeoPoint":213,"geoPoint":215,"contacts":216},"Department of Pediatrics, Triemli Hospital Zurich, Switzerland","8063",{"type":54,"coordinates":214},[201,202],{"lat":202,"lon":201},[217,221],{"name":218,"role":38,"phone":219,"phoneExt":26,"email":220},"Maren Tomaske, Prof. Dr. med.","0041 44 416 11 11","Maren.Tomaske@stadtspital.ch",{"name":218,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":223,"status":100,"city":224,"state":225,"zip":226,"country":52,"cosmosGeoPoint":227,"geoPoint":231,"contacts":232},"Institute of Pediatrics of Southern Switzerland, EOC, Bellinzona, Switzerland","Bellinzona","Canton Ticino","6500",{"type":54,"coordinates":228},[229,230],9.01703,46.19278,{"lat":230,"lon":229},[233,237],{"name":234,"role":38,"phone":235,"phoneExt":26,"email":236},"Lisa Kottanattu, Dr. med.","0041 91 811 91 11","Lisa.Kottanattu@eoc.ch",{"name":234,"role":76,"phone":26,"phoneExt":26,"email":26},{"facility":239,"status":61,"city":240,"state":241,"zip":242,"country":52,"cosmosGeoPoint":243,"geoPoint":247,"contacts":248},"Department of Pediatrics, Cantonal Hospital Graubuenden, Switzerland","Chur","Kanton Graubünden","7000",{"type":54,"coordinates":244},[245,246],9.53287,46.84986,{"lat":246,"lon":245},[249,253],{"name":250,"role":38,"phone":251,"phoneExt":26,"email":252},"Beate Deubzer, Dr. med.","0041 81 256 61 11","beate.deubzer@ksgr.ch",{"name":250,"role":76,"phone":26,"phoneExt":26,"email":26},{"type":255,"investigatorFullName":256,"investigatorTitle":257,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Christoph Berger","Prof. Dr. med.",[259,261,264],{"name":260,"class":6},"Swiss National Science Foundation",{"name":262,"class":263},"Swiss Clinical Trial Organisation","UNKNOWN",{"name":265,"class":6},"SwissPedNet","100541087",false,"NCT06325293","A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study","A Randomized Controlled Non-inferiority Trial of Placebo Versus Macrolide Antibiotics for Mycoplasma Pneumoniae Infection in Children With Community-acquired Pneumonia - the MYTHIC Study","MYTHIC","Inclusion criteria for screening phase:\n\n* Children aged 3-17 years (from 3rd up to 18th birthday) presenting to the emergency department (ED) who will be managed ambulatory or will be admitted to general ward.\n* Clinical diagnosis of CAP:\n\n  1. Diagnosis defined as the treating physician's documented diagnosis of CAP; AND\n  2. Fever ≥38.0°C (measured by any method \\[i.e., ear, axillary, rectal, or forehead site\\] in the ED or via parent report observed in the last 24h); AND\n  3. Tachypnea (defined as respiratory rate (RR) above age-specific reference value) during the assessment in ED (triage or clinical examination).\n* Written screening consent for participation in screening phase signed by parents\u002Flegal guardians and the patient if ≥14 years of age.\n\nAdditional inclusion criteria for intervention phase:\n\n* Positive Mp screening test result with the Mp IgM lateral flow assay (LFA) (grade 2 or 3).\n* Written informed consent for participation in intervention phase signed by parents or legal guardians and the patient if ≥14 years of age.\n\nExclusion criteria:\n\nExclusion criteria for screening phase:\n\n• None.\n\nExclusion criteria for intervention phase:\n\n* Contraindication to azithromycin: Documented allergy to azithromycin; cardiovascular disease, including bradycardia, arrhythmias, and\u002For QT-interval prolongation\\*; myasthenia gravis.\n\n  \\*Co-medication with arrhythmogenic or QT-interval-prolonging drug (www.qtdrugs.org) is no exclusion criteria but will be discussed with the local investigators and\u002For trial management team (TMT).\n* Underlying comorbidities: Cystic fibrosis or other chronic lung disorders (excluding asthma), primary or secondary immunodeficiency, sickle-cell anemia, or severe cerebral palsy.\n* History of recurrent pneumonia (two or more episodes) or severe pneumonia (ICU admission or complications of CAP such as lung abscess, effusion, and empyema) in lifetime.\n* Antibiotic treatment against Mp within the previous 7 days, including macrolides, tetracyclines, or fluoroquinolones.\n* Referral to ICU directly from the ED.\n* Inability to take oral medication.\n* Parents are unlikely to reliably complete follow up (FUP) visits and questionnaires (e.g., due to language barriers or living far from the study site).","ALL","3 Years","17 Years",{"count":277,"type":278},376,"ESTIMATED","INTERVENTIONAL",[281],"NA","The goal of this clinical trial is to compare a placebo (a look-alike substance that contains no active drug) with a commonly used antibiotic in children with Mycoplasma pneumoniae (a specific bacterium) induced community-acquired pneumonia. The main question it aims to answer is:\n\nIs antibiotic treatment needed in Mycoplasma pneumoniae (a specific bacterium) induced pneumonia?\n\nParticipants will receive either a placebo or a antibiotic treatment and track their symptoms and vital signs until they are healthy.\n\nResearchers will then compare the length of symptoms between the placebo and the antibiotic group.",[284,285,286],"Community Acquired Pneumonia in Children","Mycoplasma Pneumoniae","Mycoplasma Pneumoniae Pneumonia",[288,289,290,291,292,293,294,295],"Mycoplasma pneumoniae","community-acquired pneumonia","randomized controlled trial","Investigator Initiated Clinical Trial (IICT)","Paediatric pneumonia","children","placebo","macrolides","2026-04-29",{"date":298,"type":299},"2026-05-05","ACTUAL",{"date":301,"type":299},"2025-01-28",{"date":303,"type":278},"2028-12-31",{"name":256,"class":6},13]