Ablation of Pulmonary Oligometastasis Combined With System for Advanced Hepatocellular Carcinoma

diagnosis of primary HCC, confirmed histologically or clinically according to the criteria of the American Association for the Study of Liver Diseases;

presence of pulmonary oligometastasis, the metastases found within three month of HCC diagnosis;

metastases with limited five sites and no more two organs involved, with a maximum diameter of ≤5cm;

receipt of first-line systemic therapy for minimum of 3 months before ablation, with controlled intrahepatic tumors and no progression of metastases. Controlled intrahepatic tumors were defined as those showing a partial or stable response according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST);