[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564962":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":17,"studyPopulation":18,"armGroups":13,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":56,"collaborators":60,"id":69,"slug":13,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":13,"maxAge":13,"enrollmentInfo":76,"targetDuration":79,"studyType":80,"phases":13,"briefSummary":11,"conditions":81,"keywords":83,"overallStatus":37,"whyStopped":13,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Chongqing Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of PA concurrent with ACS patient","To evaluate the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of primary aldosteronism concurrent with autonomous cortisol secretion patient, using AVS and\u002For postoperative remission as the reference standard for classification diagnosis.","6 months",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","This study is a multicenter, prospective, diagnostic trial involving patients with primary aldosteronism (PA) concurrent with autonomous cortisol secretion (ACS) patients with adrenal nodule (≥1cm) who completed both AVS and 68Ga-Pentixafor PET\u002FCT. We will enroll 97 PA concurrent with ACS patients with adrenal nodule (≥1cm) .The treatment plan was determined according to the AVS results. AVS and\u002For postoperative remission were used as the reference standard for classification diagnosis to evaluate the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of PA concurrent with ACS patients.","PA concurrent with ACS patients were from The First Affiliated Hospital of Chongqing Medical University, The Affiliated Hospital of Southwest Medical University, The Third Xiangya Hospital of Central South University, The First Affiliated Hospital of Zhengzhou University and Nanjing Drum Tower Hospital.",[20],{"type":21,"name":22,"description":23,"armGroupLabels":13,"otherNames":13},"DIAGNOSTIC_TEST","68Ga-Pentixafor PET\u002FCT","The patients had a normal diet with no special preparation before 68Ga-Pentixafor PET\u002FCT imaging. The dosage of intravenously injected 68Ga-Pentixafor was calculated based on the patient\\'s weight (1.85 MBq \\[0.05mCi\\]\u002Fkg). Local PET\u002FCT scanning of the upper abdomen was performed on a hybrid PET\u002FCT scanner at 10 minutes after the injection of the intravenous tracer, respectively.",[25],{"name":26,"affiliation":27,"role":28},"Qi fu Li, PhD","the Chongqing Primary Aldosteronism Study (CONPASS) Group","STUDY_CHAIR",[30],{"name":26,"role":31,"phone":32,"phoneExt":13,"email":33},"CONTACT","86-89011552","liqifu@yeah.net",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"The First Affilated Hospital of Chongqing Medical University","RECRUITING","Chongqing","Chongqing Municipality","400016","China","CN",{"type":44,"coordinates":45},"Point",[46,47],106.55771,29.56026,{"lat":47,"lon":46},[50,53],{"name":51,"role":31,"phone":52,"phoneExt":13,"email":33},"Qifu Li, PhD","023-89011552",{"name":54,"role":31,"phone":52,"phoneExt":13,"email":55},"Ying Song, M.D.","shuiyunying@126.com",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"SPONSOR_INVESTIGATOR","Qifu Li","Primary investigator",[61,63,65,67],{"name":62,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":64,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",{"name":66,"class":6},"The Third Xiangya Hospital of Central South University",{"name":68,"class":6},"The Affiliated Hospital Of Southwest Medical University","100564962",false,"NCT06635993","Accuracy of 68Ga-Pentixafor PET\u002FCT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion","ABOARD","Inclusion Criteria:\n\n1. Getting the written informed consent\n2. The clear diagnosis of primary aldosteronism；\n3. Combined with autonomous cortisol secretion, cortisol after 1mg dexamethasone suppression test (DST) ≥50 nmol\u002Fl；\n4. Patients who are willing to undergo surgery；\n5. Adrenal CT or MRI scan of the adrenal glands with nodule (≥1cm).\n\nExclusion Criteria:\n\n1. PA patients who meet the by-passing AVS criteria \\[i.e., younger than 35 years old, spontaneous hypokalemia, adrenal CT indicated unilateral low-density adenoma (≥1cm), plasma aldosterone \\>300pg\u002Fml\\]；\n2. Suspicion of familial hyperaldosteronism or Liddle syndrome. \\[i.e., age \\<20 years, hypertension and hypokalemia, or with family history\\]；\n3. Suspicion of pheochromocytoma or adrenal carcinoma；\n4. Patients with actively malignant tumor；\n5. Patients who have adrenalectomy history；\n6. Long-term use of glucocorticoids；\n7. Patients who are allergic to contrast media and cannot tolerate AVS；\n8. Pregnant or lactating women; with alcohol or drug abuse and mental disorders；\n9. Congestive heart failure with New York Heart Association (NYHA) Functional Classification III or IV; History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 3 months; Severe anemia (Hb\\<60g\u002FL); Serious liver dysfunction or chronic kidney disease aspartate aminotransferase (AST) or alanine transaminase (ALT) ≥3 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \\<30 ml\u002Fmin\u002F1.73 m2); Systemic Inflammatory Response Syndrome (SIRS); Uncontrolled diabetes (FBG≥13.3 mmol\u002FL); Obesity (BMI≥35 kg\u002Fm²); Untreated aneurysm; Other comorbidity potentially interfering with treatment；\n10. Consider patients with bilateral cortisol hypersecretion such as PBMAH or PPNAD.","ALL",{"count":77,"type":78},97,"ESTIMATED","6 Months","OBSERVATIONAL",[82],"Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion",[84,85,86,22],"primary aldosteronism","autonomous cortisol secretion","Adrenal venous sampling","2024-10-09",{"date":89,"type":90},"2024-10-10","ACTUAL",{"date":92,"type":90},"2024-08-12",{"date":94,"type":78},"2027-08-12",{"name":58,"class":6},1]