The aim of this clinical trial is to investigate the development of cardiac decompensation following transjugular intrahepatic portosystemic shunt (TIPSS) implantation in order to draw conclusions for future treatment methods or exclusion criteria prior to TIPS implantation.
The main questions to be answered are:
How often do symptoms of cardiac decompensation develop over a one year period? What laboratory, clinical or imaging morphological changes are associated with this? In addition to the standardised clinical procedure for TIPSS implantation, participants will undergo 3 cardiac magnetic resonance imaging (MRI), extended echocardiographic examinations (both just before, 3 days after and 3 months after implantation) and laboratory chemistry tests for specific endothelial and inflammatory markers (just before, on the day of implantation, 1 day after, 1, 3, 6 and 12 months after implantation).
Age 18 to 99 years
Written informed consent of the patient
Decompensated liver cirrhosis, defined by clinical, imaging or laboratory criteria
Patient receives an elective TIPSS in the appropriate clinical context at the JUH
Pregnancy
Implants not suitable for magnetic resonance imaging
Medical/personal reasons against magnetic resonance imaging (claustrophobia, patient cannot lie flat or follow breathing commands)
Patient in critical condition or incompliant
Stephanie Gräger
Lead sponsor
Jena University Hospital
Sponsor institution
Jena University Hospital
Collaborator