[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566226":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":39,"responsibleParty":58,"collaborators":23,"id":61,"slug":23,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":23,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":23,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":42,"whyStopped":23,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low temperature (15°C) group","EXPERIMENTAL","Subjects in exposure group will be exposed to low temperature (15°C) for about 2 hours in a chamber.",[13],"Other: Low temperature (15°C) group",{"label":15,"type":10,"description":16,"interventionNames":17},"Moderate temperature (22°C) group","Subjects in exposure group will be exposed to moderate temperature (22°C) for about 2 hours in a chamber.",[18],"Other: Moderate temperature (22°C) group",[20,24],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"The exposure group will be exposed to low temperature (15°C) in a chamber for about 2 hours, resting during the whole periods.",[9],null,{"type":6,"name":15,"description":25,"armGroupLabels":26,"otherNames":23},"The exposure group will be exposed to thermoneutral temperature (22°C) in a chamber for about 2 hours, resting during the whole periods.",[15],[28],{"name":29,"affiliation":5,"role":30},"Haidong Kan, PhD","STUDY_DIRECTOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},"Renjie Chen, PhD","CONTACT","+86-021-54237908","chenrenjie@fudan.edu.cn",{"name":29,"role":34,"phone":35,"phoneExt":23,"email":38},"kanh@fudan.edu.cn",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Department of Environmental Health, School of Public Health, Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200032","China",{"type":48,"coordinates":49},"Point",[50,51],121.45806,31.22222,{"lat":51,"lon":50},[54,55,56],{"name":29,"role":34,"phone":35,"phoneExt":23,"email":38},{"name":33,"role":34,"phone":35,"phoneExt":23,"email":36},{"name":33,"role":57,"phone":23,"phoneExt":23,"email":23},"PRINCIPAL_INVESTIGATOR",{"type":57,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Renjie Chen","Professor","100566226",false,"NCT06652425","Acute Effects of Cold Exposure on Cardiovascular System","Acute Effects of Cold Exposure on Cardiovascular System and Potential Mechanism in Healthy Young Adults: A Randomized Controlled Study","Inclusion Criteria:\n\n* Living in Shanghai during the study period;\n* Body mass index \\> 18.5 and ≤ 28;\n* Right-handed;\n* Receiving or having received higher education;\n* With the ability to read and understand Chinese smoothly.\n\nExclusion Criteria:\n\n* Smoking and alcohol abuse;\n* Current drug and dietary supplements intake;\n* Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy;\n* Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension;\n* Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;\n* Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease;\n* Subjects who have a history of major surgery due to cardiovascular, cerebrovascular, respiratory, or neurological diseases;\n* Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia;\n* Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1\u002FFVC ≤ 0.65);\n* Subjects with color vision disabilities.",true,"ALL","18 Years","30 Years",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"NA","This is a randomized controlled human exposure crossover study. Investigators aim to assess the acute effects of low temperature exposure on cardiovascular system and the underlying mechanisms.",[79],"Cardiovascular System",[81,82,83],"Low temperature","Randomized controlled trial","Cardiovascular system","2025-02-25",{"date":86,"type":87},"2025-02-27","ACTUAL",{"date":89,"type":87},"2024-10-16",{"date":91,"type":73},"2026-12-31",{"name":5,"class":6},1]