[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638628":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":37,"responsibleParty":53,"collaborators":10,"id":55,"slug":10,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Istanbul University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Smokers",null,"Healthy adult participants with active cigarette smoking exposure who underwent baseline ophthalmic examination and Pentacam measurements, followed by repeat measurements after a standardized 10-minute outdoor period during which they smoked.",[13],"Other: Cigarette Smoking Exposure",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-smokers","Healthy adult participants without cigarette smoking exposure who underwent baseline ophthalmic examination and Pentacam measurements, followed by repeat measurements after a standardized 10-minute outdoor period under the same environmental conditions without smoking.",[18],"Other: No Smoking Exposure",[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"Cigarette Smoking Exposure","Participants in the smoking group smoked cigarettes during a standardized 10-minute outdoor period between baseline and post-exposure assessments.",[9],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"No Smoking Exposure","Participants in the control group remained in the same outdoor environment for 10 minutes without smoking between baseline and post-exposure assessments.",[15],[29],{"name":30,"affiliation":5,"role":31},"Semih Çakmak","PRINCIPAL_INVESTIGATOR",[33],{"name":30,"role":34,"phone":35,"phoneExt":10,"email":36},"CONTACT","902124142000","semihcakmak@istanbul.edu.tr",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Istanbul University, Istanbul Faculty of Medicine","RECRUITING","Istanbul","34093","Turkey (Türkiye)",{"type":45,"coordinates":46},"Point",[47,48],28.94966,41.01384,{"lat":48,"lon":47},[51],{"name":30,"role":34,"phone":52,"phoneExt":10,"email":36},"905375555141",{"type":31,"investigatorFullName":30,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Assistant Professor","100638628",false,"NCT07580040","Acute Ocular Effects of Cigarette Smoking","Acute Effects of Cigarette Smoking on Corneal Tomographic and Biometric Parameters: A Prospective Controlled Study","Inclusion Criteria:\n\n* Healthy adults aged 18 to 60 years\n* Current smokers in the smoking group\n* Never-smokers in the control group\n* Willing and able to undergo ophthalmic examination and Pentacam AXL measurements\n\nExclusion Criteria:\n\n* History of ocular surgery or ocular trauma\n* Presence of corneal disease, retinal disease, or ocular surface disorder\n* Clinically significant dry eye disease\n* Contact lens use within the last 2 weeks\n* Use of medications that may affect the ocular surface or pupillary dynamics, including anticholinergics or sympathomimetics\n* Systemic diseases such as diabetes mellitus or hypertension\n* Former smoking history in the control group\n* Use of electronic cigarettes or other tobacco products\n* Inability to cooperate adequately for accurate measurement",true,"ALL","18 Years","60 Years",{"count":66,"type":67},90,"ESTIMATED","OBSERVATIONAL","This prospective study aims to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults. After baseline examinations and measurements are taken in both smoking and non-smoking participants, the same measurements will be repeated after 10 minutes of external exposure, and within-group and between-group changes will be compared. The aim of the study is to determine whether acute smoking exposure leads to measurable immediate changes in corneal tomographic and biometric parameters.",[71,72,73],"Smoking ( Cigarette)","Cornea","Anterior Eye Segment Measurements",[75,76,77,78,79,80],"Cigarette Smoking","Corneal Tomography","Biometry","Pentacam","Anterior Segment","Corneal Densitometry","2026-05-05",{"date":83,"type":84},"2026-05-12","ACTUAL",{"date":86,"type":84},"2026-02-15",{"date":88,"type":67},"2026-05",{"name":5,"class":6},1]