About this trial

This clinical trial evaluates if in-person acupuncture or virtual acupressure therapy prevents aromatase inhibitor-associated joint pain in Non-Hispanic Black postmenopausal women with stage I-III (early-stage) hormone receptor positive (HR+) breast cancer. Aromatase inhibitors (AI) are medications that prevent the formation of the hormone estrogen. They are used in the treatment of postmenopausal women who have hormone-dependent breast cancer. AI therapy prolongs life among patients with early-stage HR+ breast cancer. Many postmenopausal women stop AI therapy early due to debilitating joint pain (arthralgias). Non-Hispanic Black women are more likely to experience side effects and stop their hormonal therapy compared to Non-Hispanic white women. Acupuncture therapy involves inserting thin needles through the skin at specific points on the body to control pain. Acupressure therapy uses the application of pressure or localized massage to specific sites on the body to control symptoms such as pain. Acupuncture and acupressure are types of complementary and alternative medicine. Undergoing in-person acupuncture or participating in virtual acupressure may prevent AI-associated arthralgias (AIAA) in Non-Hispanic Black postmenopausal women with early-stage HR+ breast cancer.

Eligibility criteria

Qualifiers

Age ≥ 18 years

Self-identified Non-Hispanic Black woman

Postmenopausal status (>= 12 months since last menstrual period, history of bilateral salpingo-oophorectomy, or estradiol, follicle-stimulating hormone [FSH], and luteinizing hormone [LH] levels consistent with menopause)

Diagnosed with stage I-III HR+/HER2 negative (-) breast cancer

Disqualifiers

Diagnosed with metastatic breast cancer

Premenopausal status

History of allergic reactions attributed to compounds of similar chemical or biologic composition to acupuncture needles or other agents used in study

Diagnosis of rheumatoid arthritis, multiple sclerosis, or muscular dystrophy

Trial design

Treatments tested in this trial

  • Acupressure Therapy
  • Acupuncture Therapy
  • Aromatase Inhibition Therapy
  • Discussion
  • Survey Administration

Treatment groups

150 Participants
are divided into 3 treatment groups

Locations

4
Emory Saint Joseph's Hospital30342, AtlantaGeorgia, United States
Emory University Hospital Midtown30308, AtlantaGeorgia, United States
Emory University Hospital/Winship Cancer Institute30322, AtlantaGeorgia, United States
Grady Health System30303, AtlantaGeorgia, United States

Sponsors and collaborators

Emory University

Lead sponsor

Bristol-Myers Squibb

Collaborator

National Cancer Institute (NCI)

Collaborator