[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555078":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":51,"collaborators":26,"id":55,"slug":26,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":26,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":26,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":26,"overallStatus":38,"whyStopped":26,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Propofol group","ACTIVE_COMPARATOR","Patients will receive induction of sedation as follow:\n\nContinuous propofol infusion will be given with syringe pump for maintenance, with the initial rate set at 25-75 mic\u002Fkg\u002Fmin IV during the first 10-15 min. To avoid administering sedatives at rates greater than clinically necessary, infusion rates will be gradually titrated to 25-50 mic\u002Fkg\u002Fmin and regulated with the clinical response, with an onset of peak drug action expected to occur within 2 min.",[13],"Drug: Propofol",{"label":15,"type":16,"description":17,"interventionNames":18},"Propofol combined with clonidine group","EXPERIMENTAL","Patients will receive 2 μg\u002Fkg of clonidine for injection intravenously 30 min before induction of sedation, administered over 10 min.",[19],"Drug: Propofol combined with clonidine",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Propofol","Continuous propofol infusion will be given with syringe pump for maintenance, with the initial rate set at 25-75 mic\u002Fkg\u002Fmin IV during the first 10-15 min. To avoid administering sedatives at rates greater than clinically necessary, infusion rates will be gradually titrated to 25-50 mic\u002Fkg\u002Fmin and regulated with the clinical response, with an onset of peak drug action expected to occur within 2 min.",[9],null,{"type":22,"name":28,"description":17,"armGroupLabels":29,"otherNames":26},"Propofol combined with clonidine",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Rabab M Mohamed, MD","CONTACT","00201069122935","rabmoh_30@outlook.com",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"RECRUITING","Tanta","El-Gharbia","31527","Egypt",{"type":44,"coordinates":45},"Point",[46,47],31.00192,30.78847,{"lat":47,"lon":46},[50],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Rabab Mohamed Mohamed Mohamed","Assistant Professor of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.","100555078",false,"NCT06507410","Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy","Inclusion Criteria:\n\n* Age 18-65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Patients undergoing colonoscopy.\n\nExclusion Criteria:\n\n* Patients had recent history of colonoscopy.\n* Previous colonic resection.\n* Severe heart failure (ejection fraction \\\u003C 30%).\n* Known history of hypersensitivity to propofol or clonidine and any need for anesthetic drug administration other than the study protocol.","ALL","18 Years","65 Years",{"count":64,"type":65},62,"ESTIMATED","INTERVENTIONAL",[68],"NA","The objective of this study was to compare safety, satisfaction, and efficiency outcomes of propofol versus propofol with clonidine in patients undergoing colonoscopy.",[71,23,72,73],"Clonidine","Sedation","Colonoscopy","2024-07-20",{"date":76,"type":77},"2024-07-23","ACTUAL",{"date":74,"type":77},{"date":80,"type":65},"2024-09-01",{"name":5,"class":6},1]