[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100343195":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":48,"responsibleParty":67,"collaborators":26,"id":71,"slug":26,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":26,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":51,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"wait and watch group","EXPERIMENTAL","clinical local advanced colorectal cancer (cTxN1\u002F2M0) following pre-operational adjuvant therapies and pathologically proved stageⅡ(pT0-3N0M0) without adjuvant chemotherapy",[13],"Behavioral: wait and watch",{"label":15,"type":16,"description":17,"interventionNames":18},"adjuvant chemotherapy group","ACTIVE_COMPARATOR","clinical local advanced colorectal cancer (cTxN1\u002F2M0) following preoperational adjuvant therapies and pathologically proved stageⅡ(pT0-3N0M0) with adjuvant chemotherapy",[19],"Drug: adjuvant chemotherapy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","wait and watch","clinical local advanced colorectal cancer (cTxN1\u002F2M0) following preoperational adjuvant therapies and pathologically proved stageⅡ(pT0-3N0M0),without(wait and watch) adjuvant chemotherapy",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","adjuvant chemotherapy","clinical local advanced colorectal cancer (cTxN1\u002F2M0) following preoperational adjuvant therapies and pathologically proved stageⅡ(pT0-3N0M0),with adjuvant chemotherapy",[15],[33],"mFOLFOX6",[35],{"name":36,"affiliation":37,"role":38},"Jun Huang, MD\u002FPHD","sixth affiliate hospital of Sun yatsen Hospital","STUDY_CHAIR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":26,"email":44},"Jianping Wang, MD\u002FPHD","CONTACT","+86 13808874808","wangjpgz@126.com",{"name":36,"role":42,"phone":46,"phoneExt":26,"email":47},"+86 13926451242","haungj97@mail.sysu.edu.cn",[49],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Sixth Affiliated Hospital of Sun Yat-sen University","RECRUITING","Guangzhou","Guangdong","510655","China",{"type":57,"coordinates":58},"Point",[59,60],113.25,23.11667,{"lat":60,"lon":59},[63],{"name":64,"role":42,"phone":65,"phoneExt":26,"email":66},"Jun Huang, M.D.","+8613926451242","huangj97@mail.sysu.edu.cn",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Jianping Wang","professor","100343195",false,"NCT03748485","Adjuvant Chemotherapy in Clinical Local Advanced CRC Following Preoperational Therapies and pT0-3N0M0 Diagnosis","Comparing the Treatment Efficacy in Clinical Local Advanced Colorectal Cancer (cTxN1\u002F2M0) Following Preoperational Adjuvant Therapies and Pathologically Proved StageⅡ(pT0-3N0M0)With or Without Adjuvant Chemotherapy","CANWATCH","Inclusion Criteria:\n\n* preoperative clinical tumor stage III （TxN1-2M0）CRC\n* pathological proved CRC adenocarcinoma by endoscopic biopsy\n* Post operational pathological T0-3N0M0 without high risk factors of recurrence\n* Patient able to understand and sign written informed consent\n\nExclusion Criteria:\n\n* Other malignant tumors history.\n* Complications need emergency surgery (occlusion, sub-occlusion, massive hemorrhage and abscesses).\n* Colorectal tumor extension towards abdominal wall and\u002For adjacent organ making liver R0 resection impossible immediately.\n* Non resectable lymph node metastasis.\n* American Society of Anesthesiologists (ASA) grading≥ IV and\u002For, Eastern Cooperative Oncology Group(ECOG) score≥ 2.\n* Physical or psychological dependence.\n* Pregnant or breast feeding women.\n* Not controlled pre-operational infection.\n* Enrolled in other clinical trials within 4 weeks.\n* Other clinical or laboratorial condition not recommended by investigators.","ALL","18 Years","75 Years",{"count":82,"type":83},650,"ESTIMATED","INTERVENTIONAL",[86],"NA","Adjuvant chemotherapy was unnecessary in pathological stage Ⅱ colorectal cancer following initial treatment of surgery without high risk factors of recurrences. The treatment efficacy of adjuvant chemotherapy for pT1-3N0M0 colorectal cancer following preoperational chemotherapy or chemoradiotherapy remains unclear. Part of clinical local advanced colorectal cancer(cTxN1-2M0), which turn out to be pT0-3N0M0 after preoperational chemotherapy or chemoradiotherapy, might not really need adjuvant chemotherapy due to the down-stage efficacy of the preoperational treatments, or the misleading by lymph nodes false-positive imaging diagnosis.",[89,90],"Colorectal Cancer","Adjuvant Chemotherapy",[92,29],"local advanced colorectal cancer","2026-06-05",{"date":95,"type":96},"2026-06-09","ACTUAL",{"date":98,"type":96},"2019-04-30",{"date":100,"type":83},"2030-12-30",{"name":5,"class":6},1]