[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638461":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":26,"responsibleParty":40,"collaborators":43,"id":47,"slug":26,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":26,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":26,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":74,"whyStopped":26,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":26},{"fullName":5,"class":6},"Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AI-empowered nudge group","EXPERIMENTAL","This arm implements a multi-component AI-empowered nudge strategy:\n\nDefault Appointment: On-site pre-scheduling of colonoscopies for high-risk individuals, providing an \"opt-out\" mechanism.\n\nAI Chatbot: Guided on-site use (≥3 mins) of a dedicated chatbot offering personalized responses on CRC questions to facilitate self-learning.\n\nLLM-produced SMS Reminders: For non-adherent participants, ChatGPT-5 generates risk-tailored SMS reminders sent bi-weekly to participants and their families (5 times).",[13],"Behavioral: AI-empowered nudge (AINC) strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","ACTIVE_COMPARATOR","Usual care: Based on the results of the risk assessment questionnaire and FIT test, village doctors will notify the screening results to colorectal cancer high-risk individuals, and instructs recipients to go to the designated hospital for a colonoscopy. Colonoscopy appointments will be scheduled only for residents who are willing to undergo a colonoscopy.",[19],"Other: Usual Care",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","AI-empowered nudge (AINC) strategy","A digital health education and behavioral nudge intervention. It utilizes an intelligent chatbot to provide real-time, personalized information about colonoscopy and implements a default screening mechanism to facilitate the translation from screening intention to behavior.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Usual Care","Usual notification of screening results and opt-in appointment for colonoscopy.",[15],[32],{"name":33,"affiliation":5,"role":34},"Zhiyuan Hou, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","86+21 54231112","zyhou@fudan.edu.cn",{"type":34,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Zhiyuan Hou","Associate Professor",[44],{"name":45,"class":46},"Nantong Center for Disease Control and Prevention","UNKNOWN","100638461",false,"NCT07612436","AI-empowered Nudge to Improve Colonoscopy Uptake (AINC)","AI-empowered Nudge to Improve Colonoscopy Uptake (AINC): A Pragmatic Cluster-Randomized Trial","Inclusion Criteria:\n\n* Aged 45-74 years;\n* Test positive on the Colorectal Cancer Risk Assessment Scale and the immunochemical fecal occult blood test;\n* In good general health, mentally competent;\n* Provide informed consent.\n\nExclusion Criteria:\n\n* History of colorectal resection;\n* Previous diagnosis of cancer or currently undergoing any cancer-related treatment;\n* Underwent a colonoscopy or sigmoidoscopy within the past 5 years;\n* Contraindications to colonoscopy (e.g. severe cardiac, cerebral, lung diseases, or renal dysfunction).",true,"ALL","45 Years","74 Years",{"count":58,"type":59},1680,"ESTIMATED","INTERVENTIONAL",[62],"NA","Colorectal cancer (CRC) ranks third in both incidence and mortality among all malignant tumors in China. Studies have shown that early screening can significantly reduce its incidence and mortality. Colonoscopy is the gold standard for CRC screening; however, compliance with colonoscopy among high-risk groups in China is very low. Artificial intelligence (AI)-assisted tools can provide real-time, personalized health education, and nudge strategies can help translate intent into action. This trial aims to evaluate the effectiveness of AI-empowered nudge for improving colonoscopy uptake among high-risk individuals aged 45 to 74 in China. It's a two-arm, pragmatic cluster randomized controlled trial. The main question it aims to answer is whether the AI-enabled personalized health education and nudge strategies improve colonoscopy adherence.\n\nParticipants will:\n\n1. Be recruited and allocated into one of two groups according to the assigned clusters. Participants in one group will be invited to receive usual care. In addition to usual care, participants in the other group will receive AI-empowered nudge, featuring an AI chatbot providing real-time personalized responses and a nudge environment with default screening option.\n2. Have their colonoscopy status checked at the end of trial.",[65,66],"Colorectal Neoplasms","Colonoscopy",[68,69,70,71,72,73],"Colorectal cancer","artificial intelligence","screening adherence","randomized controlled trial","nudge","Behavioral intervention","NOT_YET_RECRUITING","2026-06-03",{"date":77,"type":78},"2026-06-04","ACTUAL",{"date":80,"type":59},"2026-05-30",{"date":82,"type":59},"2027-12-31",{"name":5,"class":6}]