[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640403":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":57,"slug":26,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":26,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Clinical Center Niš","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"AI-Guided CBT","EXPERIMENTAL","Participants in this group will receive AI-guided cognitive behavioral therapy delivered through a digital platform. The intervention will consist of structured weekly sessions lasting 45-60 minutes over a period of 10 weeks, conducted under clinical supervision.",[13],"Behavioral: AI-Guided Cognitive Behavioral Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Traditional CBT","ACTIVE_COMPARATOR","Participants in this group will receive standard psychiatric care, including routine clinical monitoring and treatment as determined by their treating clinician, without access to the AI-guided CBT intervention.",[19],"Behavioral: Cognitive Behavioral Therapy (CBT)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","AI-Guided Cognitive Behavioral Therapy","AI-guided cognitive behavioral therapy delivered through a digital platform, consisting of structured weekly sessions over 10 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Cognitive Behavioral Therapy (CBT)","Cognitive behavioral therapy delivered by a trained therapist in a standard clinical format, consisting of structured weekly sessions over a 10-week period.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Aleksandra Stojanovic, MD, PhD Candidate","CONTACT","+381642293541","drakiwatson@gmail.com",[38],{"facility":39,"status":40,"city":41,"state":26,"zip":42,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University Clinical Center Niš","RECRUITING","Niš","18000","Serbia",{"type":45,"coordinates":46},"Point",[47,48],21.90333,43.32472,{"lat":48,"lon":47},[51],{"name":52,"role":34,"phone":35,"phoneExt":26,"email":36},"Aleksandra Stojanović, MD, PHD candidate",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Aleksandra Stojanovic","Dr","100640403",false,"NCT07576686","AI-Guided CBT for Depression and Anxiety","The Significance of Artificial Intelligence-Guided Psychotherapy of Depression and Anxiety Disorders","AI-CBT-DA","Inclusion Criteria:\n\nAge 18 years or older Diagnosis of mild depressive disorder and\u002For anxiety disorder confirmed by a structured clinical interview (MINI) Ability to understand and provide informed consent Access to a device capable of using the digital platform (computer, tablet, or smartphone) Willingness to participate in weekly sessions over a 10-week period\n\nExclusion Criteria:\n\nModerate to severe depressive disorder Current or past diagnosis of psychotic disorder Bipolar disorder Substance use disorder or dependence Primary diagnosis of antisocial personality disorder Severe cognitive impairment or inability to use digital tools Acute suicidal risk requiring immediate intervention Concurrent participation in another structured psychotherapy program-","ALL","18 Years",{"count":67,"type":68},120,"ESTIMATED","INTERVENTIONAL",[71],"NA","This study aims to evaluate the effectiveness of an artificial intelligence (AI)-guided cognitive behavioral therapy (CBT) program for the treatment of mild depression and anxiety disorders in adults.\n\nDepression and anxiety disorders are among the most common mental health conditions worldwide and are associated with significant individual and societal burden. Despite the availability of effective treatments, access to psychotherapy remains limited due to insufficient resources and long waiting times. Digital mental health interventions, particularly those supported by artificial intelligence, have the potential to increase accessibility and scalability of evidence-based treatments.\n\nIn this controlled clinical trial, participants diagnosed with mild depressive disorder and\u002For anxiety disorders will be assigned to either an experimental group receiving AI-guided CBT or a control group receiving standard psychiatric care. The intervention will be delivered through a digital platform and will consist of structured weekly sessions over a 10-week period.\n\nThe primary objective of the study is to assess changes in symptoms of depression and anxiety. Secondary outcomes include perceived stress, social support, digital therapeutic alliance, and overall clinical improvement.\n\nThe findings of this study are expected to contribute to the understanding of the role of AI in psychotherapy and its potential to improve access to mental health care.",[74,75],"Depression - Major Depressive Disorder","Anxiety Disorders",[77,78,79,80,81,82,83,84,85],"AI-guided psychotherapy","Cognitive Behavioral Therapy","Digital Mental Health","Depression","Anxiety","Artificial Intelligence","Digital Therapeutic Alliance","eHealth","Internet-based CBT","2026-05-01",{"date":88,"type":89},"2026-05-08","ACTUAL",{"date":91,"type":89},"2026-01-07",{"date":93,"type":68},"2026-06-10",{"name":55,"class":6},1]