[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621090":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":24,"studyPopulation":17,"armGroups":25,"interventions":33,"overallOfficials":17,"centralContacts":43,"locations":53,"responsibleParty":69,"collaborators":17,"id":71,"slug":17,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":17,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":17,"studyType":83,"phases":84,"briefSummary":85,"conditions":86,"keywords":17,"overallStatus":55,"whyStopped":17,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Peking Union Medical College Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Diagnostic value","Sensitivity and specificity of Al18F-NOTA-LM3 PET\u002FCT for TIO in comparison with 68Ga-DOTATATE PET\u002FCT","From study completion to 6 months after completion.",[14],{"measure":15,"description":16,"timeFrame":12},"standardized uptake value (SUV) of tumor","Compare the SUVmax of tumor derived from Al18F-NOTA-LM3 and 68Ga-DOTATATE PET\u002FCT.",null,{"allocation":19,"interventionModel":20,"interventionModelDescription":17,"primaryPurpose":21,"observationalModel":17,"timePerspective":17,"maskingInfo":22},"NA","SINGLE_GROUP","DIAGNOSTIC",{"masking":23,"maskingDescription":17,"whoMasked":17},"NONE","Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. The main cure for TIO is surgical removal of the responsible tumor. Somatostatin receptors (SSTR) targeted PET imaging with radiolabeled somatostatin analogs can help locate these tumors. It can detect culprit tumors in TIO patients, even small ones that CT or MRI might miss. 68Ga-DOTATATE is the most commonly used SSTR PET tracer for TIO, recommended as the first-line imaging tool to find the causative tumor.\n\nCompared to 68Ga-based tracers, 18F-labelled radiotracers offer several advantages, including higher cyclotron production, lower positron energy, and longer half-life. These features may improve image quality. Al18F-NOTA-LM3 is an SSTR2 specific antagonist used as a PET tracer. This pilot study is designed to compare Al18F-NOTA-LM3 with 68Ga-DOTATATE in the same group of TIO patients.",[26],{"label":27,"type":28,"description":29,"interventionNames":30},"Al18F-NOTA-LM3 and 68Ga-DOTATATE PET\u002FCT scan","EXPERIMENTAL","Patients of TIO PET\u002FCT imaging: Patients will perform an Al18F-NOTA-LM3 PET\u002FCT as well as a 68Ga-DOTATATE PET\u002FCT.",[31,32],"Drug: Diagnostic Test: Al18F-NOTA-LM3","Drug: Diagnostic Test: 68Ga-DOTATATE",[34,39],{"type":35,"name":36,"description":37,"armGroupLabels":38,"otherNames":17},"DRUG","Diagnostic Test: Al18F-NOTA-LM3","Al18F-NOTA-LM3 will be injected into the patients. Patients will undergo a whole-body PET\u002FCT scan 60-120 minutes after injection.",[27],{"type":35,"name":40,"description":41,"armGroupLabels":42,"otherNames":17},"Diagnostic Test: 68Ga-DOTATATE","68Ga-DOTATATE will be injected into the patients. Patients will undergo a whole-body PET\u002FCT scan 40-60 minutes after injection.",[27],[44,49],{"name":45,"role":46,"phone":47,"phoneExt":17,"email":48},"Hongli Jing","CONTACT","18600586399","annsmile1976@sina.com",{"name":50,"role":46,"phone":51,"phoneExt":17,"email":52},"Yuwei Zhang","18511071577","ywzhangwork@163.com",[54],{"facility":5,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Beijing","Beijing Municipality","100730","China","CN",{"type":62,"coordinates":63},"Point",[64,65],116.39723,39.9075,{"lat":65,"lon":64},[68],{"name":45,"role":46,"phone":47,"phoneExt":17,"email":48},{"type":70,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR","100621090",false,"NCT07366099","Al18F-NOTA-LM3 PET\u002FCT in Patients With TIO","Application of Al18F-NOTA-LM3 PET\u002FCT in the Diagnosis and Evaluation of Tumor-Induced Osteomalacia","Inclusion Criteria:\n\n* Patients aged 18 to 80 years.\n* Suspected or confirmed TIO patients.\n\nExclusion Criteria:\n\n* Combined with other types of tumors.\n* Severe liver or renal dysfunction (ALT\u002FAST≥5 ULN, GFR\\\u003C30ml\u002Fmin).\n* Pregnant or breast-feeding women.\n* Inability to perform PET\u002FCT scans.","ALL","18 Years","80 Years",{"count":81,"type":82},40,"ESTIMATED","INTERVENTIONAL",[19],"This is a pilot study to assess the value of whole-body Al18F-NOTA-LM3 PET\u002FCT in patients with tumor-induced osteomalacia.",[87],"Tumor-Induced Osteomalacia","2026-01-18",{"date":90,"type":91},"2026-01-26","ACTUAL",{"date":93,"type":91},"2023-03-30",{"date":95,"type":82},"2026-05-30",{"name":5,"class":6},1]