About this trial

A unique approach for cancer treatment employing intratumoral diffusing alpha radiation emitter device for advanced pancreatic cancer

Eligibility criteria

Qualifiers

Histologically and/or cytologically proven locally advanced or metastatic pancreatic adenocarcinoma

Patients must have i) received at least one line of chemotherapy OR ii) are medically unfit for further chemotherapy, AND iii) the tumor is still not deemed as resectable with radical surgery or the patient does not wish to go through surgery

Target lesion is technically amenable for at least 50% coverage by the Alpha DaRT seeds as determined by the treating physician

Interstitial radiation indication validated by a multidisciplinary team

Disqualifiers

Concomitant chemotherapy or immunotherapy within the past 4 weeks

Brain metastases

Borderline unresectable pancreatic cancer, and/or cases fit for surgical exploration unless patient refuses surgery

Known hypersensitivity to any of the components of the treatment.

Trial design

Treatments tested in this trial

  • Radiation: Diffusing Alpha Radiation Emitters Therapy (DaRT)

Treatment groups

15 Participants
are divided into 1 treatment group

Locations

2
Wolfson Medical Center Holon Israel
Hadassah Ein Kerem Jerusalem Israel

Sponsors and collaborators

Alpha Tau Medical LTD.

Lead sponsor