[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517366":3},{"organization":4,"outcomesModule":7,"designInfo":17,"detailedDescription":16,"studyPopulation":20,"armGroups":21,"interventions":26,"overallOfficials":32,"centralContacts":37,"locations":43,"responsibleParty":59,"collaborators":16,"id":62,"slug":16,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":16,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":16,"enrollmentInfo":70,"targetDuration":16,"studyType":73,"phases":16,"briefSummary":74,"conditions":75,"keywords":16,"overallStatus":45,"whyStopped":16,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Harbin Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":16},[9,13],{"measure":10,"description":11,"timeFrame":12},"Task1: MACE","All cause death, stroke, myocardial reinfarction, unplanned revascularization, lower extremity artery disease","1 year",{"measure":14,"description":15,"timeFrame":12},"Task2: Plaque characteristics","Plaque morphology on OCT",null,{"allocation":16,"interventionModel":16,"interventionModelDescription":16,"primaryPurpose":16,"observationalModel":18,"timePerspective":19,"maskingInfo":16},"COHORT","PROSPECTIVE","Patients with polyvascular disease in the 2nd Affiliated Hospital of Harbin Medical University",[22],{"label":23,"type":16,"description":16,"interventionNames":24},"Polyvascular disease",[25],"Diagnostic Test: Magnetic Resonance Angiography, Ocular OCTA, CT Angiography",[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":16},"DIAGNOSTIC_TEST","Magnetic Resonance Angiography, Ocular OCTA, CT Angiography","Magnetic Resonance Angiography of intracranial artery, carotid artery, renal artery and lower extremity artery, CT angiography of coronary artery or intracranial artery",[23],[33],{"name":34,"affiliation":35,"role":36},"Haibo Jia, MD. Ph.D","The Second Affiliated Hospital of Harbin Medical University","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":16,"email":42},"Minghao Liu, MD.","CONTACT","+8613764166251","baiyuedao@alumni.sjtu.edu.cn",[44],{"facility":35,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Harbin","Heilongjiang","150000","China","CN",{"type":52,"coordinates":53},"Point",[54,55],126.65,45.75,{"lat":55,"lon":54},[58],{"name":39,"role":40,"phone":41,"phoneExt":16,"email":42},{"type":36,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":16,"oldOrganization":16},"Yu Bo","Director","100517366",false,"NCT06016608","An Imaging Study of Polyvascular Disease","Early Screen, Systematic Evaluation and Risk Warning of Polyvascular Disease Based on Multi-modality Imaging","Inclusion Criteria:\n\nTask 1:\n\n1. Patients with coronary artery disease (≥50% stenosis in any coronary artery on coronary angiography)\n2. Age ≥18 years old\n3. Proposed OCT-IVUS integrated imaging system\n4. able to provide written informed consent prior to the start of any procedures related to the study.\n\nTask 2:\n\n1. patients with coronary artery disease (coronary angiography reveals ≥50% degree of stenosis in any coronary artery) and patients with stroke or TIA (confirmed by a neurologist)\n2. Age ≥ 18 years\n3. able to provide written informed consent prior to the start of any procedures related to the study.\n\nExclusion Criteria:\n\nTask 1:\n\n1. severely tortuous\u002Fcalcified coronary arteries with anticipated difficulty in completing the OCT-IVUS integrated imaging system\n2. uncontrolled congestive heart failure or acute left heart failure;plan\n3. claustrophobia;\n4. left main stem occlusion;\n5. proposed coronary artery bypass grafting (CABG);\n6. uncontrolled severe ventricular arrhythmia;\n7. active bleeding or severe bleeding tendency;\n8. acute stroke;\n9. patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ;\n10. severe renal insufficiency and\u002For anuria, except in cases where dialysis treatment has been planned;\n11. contraindications to the application of contrast media;\n12. patients who are severely uncooperative due to psychiatric or serious systemic illness;\n13. Patients who, in the opinion of the investigator, are unsuitable for participation in the study.\n\nTask 2:\n\n1. patients who are unable to comply with the follow-up schedule;\n2. uncontrolled congestive heart failure or acute left heart failure;\n3. patients with a life expectancy of less than 6 months;\n4. left main stem occlusion;\n5. proposed coronary artery bypass grafting (CABG);\n6. uncontrolled severe ventricular arrhythmia;\n7. active bleeding or severe bleeding tendency;\n8. patients with hemodynamic instability or unstable cardiac electrical activity (including shock) ;\n9. severe renal insufficiency and\u002For anuria, except in cases where dialysis treatment has been planned;\n10. contraindications to the application of contrast media;\n11. patients who are severely uncooperative due to psychiatric or serious systemic illness;\n12. patients who, in the opinion of the investigator, are not suitable for participation in the study.","ALL","18 Years",{"count":71,"type":72},1100,"ESTIMATED","OBSERVATIONAL","1. Establish a multimodality imaging database for PVD, improve the one-stop screening process for early PVD based on artificial intelligence, build a full-cycle control information platform, and promote the construction and standardization of a multidisciplinary co-morbidity and co-management diagnosis and treatment model.\n2. Based on non-invasive, zero-contrast ocular OCTA combined with one-stop CTA imaging of the heart and brain, construct an integrated \"eye-heart-brain\" early warning model for PVD, and explore a potential non-invasive and convenient early warning system for PVD.\n3. Based on the multi-omics, investigate EVs-mediated intercellular communication network, elucidate the roles and regulatory mechanisms of EVs in the development of PVD, search for potential targets for intervention, and construct an artificial intelligence-based \"pan-vascular score\" risk assessment system based on the combination of multi-modality imaging and multi-omics biomarkers.",[76],"Polyvascular Disease","2024-12-22",{"date":79,"type":80},"2024-12-27","ACTUAL",{"date":82,"type":80},"2023-10-18",{"date":84,"type":72},"2025-12-31",{"name":5,"class":6},1]