[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100371178":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":18,"locations":28,"responsibleParty":313,"collaborators":7,"id":315,"slug":7,"hasResults":316,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":7,"eligibilityCriteria":320,"healthyVolunteers":316,"sex":321,"minAge":322,"maxAge":7,"enrollmentInfo":323,"targetDuration":326,"studyType":327,"phases":7,"briefSummary":328,"conditions":329,"keywords":332,"overallStatus":31,"whyStopped":7,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":343},{"fullName":5,"class":6},"AO Innovation Translation Center","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"PROCEDURE","Any treatment that is used for a defect of any long bone","Any treatment that is used for a defect of any long bone. All treatments are based on individual clinician's judgement and the patient characteristics. The registry does not dictate any specific treatment.",[14],{"name":15,"affiliation":16,"role":17},"Hans-Christoph Pape, MD","University Hospital Zurich Department of Trauma Surgery","PRINCIPAL_INVESTIGATOR",[19,24],{"name":20,"role":21,"phone":22,"phoneExt":7,"email":23},"Marco Minoia","CONTACT","+41 79 612 09 67","marco.minoia@aofoundation.org",{"name":25,"role":21,"phone":26,"phoneExt":7,"email":27},"Joelle Kägi","+41 79 549 32 83","joelle.kaegi@aofoundation.org",[29,46,59,73,87,101,112,124,137,150,159,171,187,201,215,228,242,255,268,282,295],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Cedar Sinai","RECRUITING","Los Angeles","California","90048","United States",{"type":37,"coordinates":38},"Point",[39,40],-118.24368,34.05223,{"lat":40,"lon":39},[43],{"name":44,"role":21,"phone":7,"phoneExt":7,"email":45},"Geoffrey Marecek, 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Pablo Tobon Uribe","Medellín",{"type":37,"coordinates":116},[117,118],-75.57151,6.245,{"lat":118,"lon":117},[121],{"name":122,"role":21,"phone":7,"phoneExt":7,"email":123},"Carlos Oliver Valderrama-Molina, MD","cvalderrama@hptu.org.co",{"facility":125,"status":31,"city":126,"state":7,"zip":7,"country":127,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"University Hospital Frankfurt","Frankfurt","Germany",{"type":37,"coordinates":129},[130,131],10.53333,49.68333,{"lat":131,"lon":130},[134],{"name":135,"role":21,"phone":7,"phoneExt":7,"email":136},"Ingo Marzi, MD","marzi@trauma.uni-frankfurt.de",{"facility":138,"status":31,"city":139,"state":7,"zip":140,"country":127,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Universitätsspital Gießen","Giessen","35385",{"type":37,"coordinates":142},[143,144],8.67554,50.58727,{"lat":144,"lon":143},[147],{"name":148,"role":21,"phone":7,"phoneExt":7,"email":149},"Christian Heiss, Prof Dr Dr","christian.heiss@chiru.med.uni-giessen.de",{"facility":151,"status":152,"city":153,"state":7,"zip":7,"country":127,"cosmosGeoPoint":154,"geoPoint":158,"contacts":7},"Universitätsklinikum Heidelberg (Unfallchirurgie)","TERMINATED","Heidelberg",{"type":37,"coordinates":155},[156,157],8.69079,49.40768,{"lat":157,"lon":156},{"facility":160,"status":31,"city":161,"state":7,"zip":7,"country":127,"cosmosGeoPoint":162,"geoPoint":166,"contacts":167},"Universitätsklinikum Münster (Klinik und Poliklinik für Unfall-, Hand- und Wiederherstellungschirurgie)","Münster",{"type":37,"coordinates":163},[164,165],7.62571,51.96236,{"lat":165,"lon":164},[168],{"name":169,"role":21,"phone":7,"phoneExt":7,"email":170},"Steffen Rosslenbroich, MD","Steffen.Rosslenbroich@ukmuenster.de",{"facility":172,"status":173,"city":174,"state":7,"zip":175,"country":127,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Krankenhaus Johanneum","NOT_YET_RECRUITING","Wildeshausen","27793",{"type":37,"coordinates":177},[178,179],8.43375,52.89446,{"lat":179,"lon":178},[182,186],{"name":183,"role":21,"phone":184,"phoneExt":7,"email":185},"Ahmed Yaseen","+4917671973159","Yaseen.Ahmed@krankenhaus-johanneum.de",{"name":183,"role":17,"phone":7,"phoneExt":7,"email":7},{"facility":188,"status":31,"city":189,"state":7,"zip":190,"country":191,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Paras HMRI Hospital Patna","Patna","800014","India",{"type":37,"coordinates":193},[194,195],85.13563,25.59408,{"lat":195,"lon":194},[198],{"name":199,"role":21,"phone":7,"phoneExt":7,"email":200},"John Mukhopadhaya, MD","mukhoj@gmail.com",{"facility":202,"status":31,"city":203,"state":7,"zip":7,"country":204,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"Academisch Ziekenhuis Maastricht (Dept. of Surgery)","Maastricht","Netherlands",{"type":37,"coordinates":206},[207,208],5.68889,50.84833,{"lat":208,"lon":207},[211],{"name":212,"role":21,"phone":213,"phoneExt":7,"email":214},"Martijn Poeze, MD","+31433871956","m.poeze@mumc.nl",{"facility":216,"status":31,"city":217,"state":7,"zip":218,"country":204,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Radboud University Medical Center","Nijmegen","6525",{"type":37,"coordinates":220},[221,222],5.85278,51.8425,{"lat":222,"lon":221},[225],{"name":226,"role":21,"phone":7,"phoneExt":7,"email":227},"Michael Edwards, MD","michael.edwards@radboudumc.nl",{"facility":229,"status":173,"city":230,"state":7,"zip":231,"country":232,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Tygerberg Hospital","Cape Town","7505","South Africa",{"type":37,"coordinates":234},[235,236],18.42322,-33.92584,{"lat":236,"lon":235},[239],{"name":240,"role":21,"phone":7,"phoneExt":7,"email":241},"Nando Ferreira","NFERREIRA@sun.ac.za",{"facility":243,"status":31,"city":244,"state":7,"zip":7,"country":245,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Kyungpook National University Hospital (Orthopaedics)","Daegu","South Korea",{"type":37,"coordinates":247},[248,249],128.59111,35.87028,{"lat":249,"lon":248},[252],{"name":253,"role":21,"phone":7,"phoneExt":7,"email":254},"Chang-Wug Oh, MD","cwoh@knu.ac.kr",{"facility":256,"status":31,"city":257,"state":7,"zip":7,"country":258,"cosmosGeoPoint":259,"geoPoint":263,"contacts":264},"Universitätsspital Zürich (Klinik für Traumatologie)","Zurich","Switzerland",{"type":37,"coordinates":260},[261,262],8.55,47.36667,{"lat":262,"lon":261},[265],{"name":15,"role":21,"phone":266,"phoneExt":7,"email":267},"+ 41 (0)44 255 27 55","Hans-Christoph.Pape@usz.ch",{"facility":269,"status":173,"city":270,"state":7,"zip":7,"country":271,"cosmosGeoPoint":272,"geoPoint":276,"contacts":277},"Central Hospital of Border Guard Service of Ukraine","Kyiv","Ukraine",{"type":37,"coordinates":273},[274,275],30.5238,50.45466,{"lat":275,"lon":274},[278,281],{"name":279,"role":21,"phone":7,"phoneExt":7,"email":280},"Dmytro Smolianets","smolianets.dmytro@gmail.com",{"name":279,"role":17,"phone":7,"phoneExt":7,"email":7},{"facility":283,"status":173,"city":284,"state":7,"zip":7,"country":285,"cosmosGeoPoint":286,"geoPoint":290,"contacts":291},"Leeds General Infirmary University Hospital (Trauma & Orthopaedic Surgery)","Leeds","United Kingdom",{"type":37,"coordinates":287},[288,289],-1.54785,53.79648,{"lat":289,"lon":288},[292],{"name":293,"role":21,"phone":7,"phoneExt":7,"email":294},"Peter Giannoudis, MD","peter.giannoudis@nhs.net",{"facility":296,"status":173,"city":297,"state":7,"zip":7,"country":298,"cosmosGeoPoint":299,"geoPoint":303,"contacts":304},"Hospital Universitario de Caracas","Caracas","Venezuela",{"type":37,"coordinates":300},[301,302],-66.87919,10.48801,{"lat":302,"lon":301},[305,309,310],{"name":306,"role":21,"phone":307,"phoneExt":7,"email":308},"Manuel Malaret","+584143119338","manuel.malaret.b@gmail.com",{"name":306,"role":17,"phone":7,"phoneExt":7,"email":7},{"name":311,"role":312,"phone":7,"phoneExt":7,"email":7},"Igor Escalante","SUB_INVESTIGATOR",{"type":314,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100371178",false,"NCT04112992","An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects","An International, Multicenter, Prospective Registry to Investigate Treatment Options and Their Outcomes on Post-traumatic Long Bones Defects","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Skeletally mature\n* Post traumatic bone defect \\> 2 cm either\n\n  * initially after injury or\n  * after surgical debridement\n* Informed consent obtained, i.e.:\n\n  * Ability to understand the content of the patient information\u002FICF\n  * Willingness and ability to participate in the clinical investigation according to the registry plan\n  * Signed and dated EC\u002FIRB approved written informed consent OR\n  * Written consent provided according to the IRB\u002FEC defined and approved procedures for patients who are not able to provide independent written informed consent\n\nExclusion Criteria:\n\n* Any oblique defect that has less than 8cm expansion when adding the defect size of all four cortices\n* Any not medically managed severe systemic disease\n* Pregnancy\n* Prisoners\n* Participation in any other medical device or medicinal product registry within the previous 3 months that could influence the results of the present registry","ALL","18 Years",{"count":324,"type":325},600,"ESTIMATED","1 Year","OBSERVATIONAL","Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group.\n\nReports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations.\n\nIn a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.",[330,331],"Limb Fracture","Bone Loss",[333],"long bone defect","2025-08-28",{"date":336,"type":337},"2025-08-29","ACTUAL",{"date":339,"type":337},"2024-07-03",{"date":341,"type":325},"2029-03-30",{"name":5,"class":6},21]