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Pederzoli","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":26,"otherOutcomes":39},[9,13,16,18,20,22,24],{"measure":10,"description":11,"timeFrame":12},"Gait speed (6MWT)","• Assess the effect of exercise on physical performance and quality of life on pa-tients with chronic kidney disease from stage 1 to end stage renal disease on maintenance haemodialysis or on conservative treatment","through study completion, an average of 1 year",{"measure":14,"description":15,"timeFrame":12},"Physical performance (SPPB)",null,{"measure":17,"description":15,"timeFrame":12},"Cardiopulmonary capacity (CPET)",{"measure":19,"description":15,"timeFrame":12},"Lower limbs strength (1-RM)",{"measure":21,"description":15,"timeFrame":12},"Maximum isometric strength of the upper limb (hand grip)",{"measure":23,"description":15,"timeFrame":12},"Daily physical activity amount (IPAQ)",{"measure":25,"description":15,"timeFrame":12},"Quality of life (SF36)",[27,29,31,33,35,37],{"measure":28,"description":15,"timeFrame":12},"Nutritional status (24HR, FFQ)",{"measure":30,"description":15,"timeFrame":12},"Body composition (DEXA, BIVA)",{"measure":32,"description":15,"timeFrame":12},"Psychological and psychosocial conditions (BDI, MMSE)",{"measure":34,"description":15,"timeFrame":12},"Hemodynamic and vascular functions (SV, CO, HR, FBF, FMD, sPLM)",{"measure":36,"description":15,"timeFrame":12},"Muscular oxygen extraction (NIRS)",{"measure":38,"description":15,"timeFrame":12},"Neuromuscular functions (MCV, RFD)",[40,43],{"measure":41,"description":42,"timeFrame":12},"effect of physical activity on mitochondrial activity","Investigate the effect of physical activity on mitochondrial activity by analyzing the expression of mitochondrial biomarkers, MOTS-c (mg)",{"measure":44,"description":45,"timeFrame":12},"Effect of physical activity on mitochondrial activity","Investigate the effect of physical activity on mitochondrial activity by analyzing the expression of mitochondrial biomarkers, humanin (mg)",{"allocation":47,"interventionModel":48,"interventionModelDescription":15,"primaryPurpose":6,"observationalModel":15,"timePerspective":15,"maskingInfo":49},"RANDOMIZED","PARALLEL",{"masking":50,"maskingDescription":15,"whoMasked":51},"SINGLE",[52],"PARTICIPANT",[54,60],{"label":55,"type":56,"description":57,"interventionNames":58},"combined exercise","EXPERIMENTAL","participants will undergo a combined endurance and resistance exercise training",[59],"Other: Exercise",{"label":61,"type":62,"description":63,"interventionNames":64},"control group","ACTIVE_COMPARATOR","participants performs outcome measures sessions only, including blood sample collection.",[65],"Other: control",[67,71],{"type":6,"name":68,"description":69,"armGroupLabels":70,"otherNames":15},"Exercise","All participants will be involved in the exercise training three times per week for 24 weeks: endurance exercise training, resistant exercise training",[55],{"type":6,"name":72,"description":73,"armGroupLabels":74,"otherNames":15},"control","outcome measures",[61],[76],{"facility":77,"status":78,"city":79,"state":80,"zip":81,"country":82,"countryCode":83,"cosmosGeoPoint":84,"geoPoint":89,"contacts":90},"Ospedale P. Pederzoli Casa di Cura Privata S.p.A.","RECRUITING","Peschiera del Garda","Verona","37019","Italy","IT",{"type":85,"coordinates":86},"Point",[87,88],10.68614,45.43912,{"lat":88,"lon":87},[91],{"name":92,"role":93,"phone":94,"phoneExt":15,"email":95},"Yuri Battaglia, MD","CONTACT","+39 0456444193","urc@ospedalepederzoli.it",{"type":97,"investigatorFullName":15,"investigatorTitle":15,"investigatorAffiliation":15,"oldNameTitle":15,"oldOrganization":15},"SPONSOR","100626620",false,"NCT07438002","Analysis of Effects of High-intensity Physical Exercise in Subjects With Dialyzed Chronic Kidney Disease and in Conservative Treatment","Effect of Exercise in Patients With Chronic Kidney Disease: TONE Trial","TONE","Inclusion Criteria:\n\n* Signature of the informed consent\n* Patients with CKD stage 1 to 5 under conservative treatment\n* Patients undergoing chronic hemodialysis for at least 3 months\n* Age ≥ 18\n\nExclusion Criteria:\n\n* Severe cardiovascular disease (NYHA class IV or hypertension class III)\n* TIA or myocardial ischemia within the last three months\n* Anatomical limitations\n* Health conditions detected during the stress test (CPET)","ALL","18 Years",{"count":108,"type":109},50,"ESTIMATED","INTERVENTIONAL",[112],"NA","This study aims to analyze the effects of physical activity in patients with chronic kidney disease undergoing dialysis or conservative treatment. Patients will be randomized into two groups: combined exercise (high-intensity aerobic resistance + strength training) and control group",[115],"Chronic Kidney Disease",[117,118,119],"Nephrology","exercise","physical activity","2026-02-20",{"date":122,"type":123},"2026-02-27","ACTUAL",{"date":125,"type":123},"2025-09-02",{"date":127,"type":109},"2026-09",{"name":5,"class":6},1]