[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545311":3},{"organization":4,"outcomesModule":7,"designInfo":26,"detailedDescription":30,"studyPopulation":31,"armGroups":32,"interventions":42,"overallOfficials":47,"centralContacts":51,"locations":27,"responsibleParty":56,"collaborators":27,"id":59,"slug":27,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":27,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":27,"studyType":71,"phases":27,"briefSummary":72,"conditions":73,"keywords":27,"overallStatus":75,"whyStopped":27,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":27},{"fullName":5,"class":6},"Kuopio University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":16},[9],{"measure":10,"description":11,"timeFrame":12},"Neuroimaging","Transcranial magnetic stimulation (TMS) combined with electroencephalogram (EEG)","Baseline and at 3 years' follow-up",[14],{"measure":10,"description":15,"timeFrame":12},"Magnetic resonance imaging (MRI)",[17,20,23],{"measure":18,"description":19,"timeFrame":12},"Psychiatric evaluation","Self-rated questionnaires measuring somatic and mentalh health (such as EDE-Q, BDI, substance use measurements) and structured psychiatric diagnostic interview (SCID)",{"measure":21,"description":22,"timeFrame":12},"Body composition measurement","InBody body composition measurement (non-invasive method to measure information about the quantity and segmentation of muscle, bone and fat tissue in body and about your basal metabolic rate)",{"measure":24,"description":25,"timeFrame":12},"Laboratory tests","Blood sample (markers describing undernourishment, more precise description before study)",{"allocation":27,"interventionModel":27,"interventionModelDescription":27,"primaryPurpose":27,"observationalModel":28,"timePerspective":29,"maskingInfo":27},null,"CASE_CONTROL","PROSPECTIVE","Anorexia nervosa is severe mental health problem with increased incidence rates in adolescence. Etiology of anorexia nervosa is still mostly unkonwn. Adolescence is also critical period of brain development.\n\nAims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in both acute and remission state of anorexia nervosa in adolescence.\n\nStudy group are young anorexia nervosa patients, and control group are healthy same-aged students.\n\nResearch methods include non-invasive brain imaging methods such as Transcranial Magnetic Stimulation (TMS), and Magnetic Resonance Imaging (MRI). Other research methods are assessment of body composition, laboratory tests, self-rated questionnaires and psychiatric interview.","Target study population is 50 participants. Study group (25 participants) are recruited from North Savo wellbeing services, Adolescent psychiatry outpatient clinic. Control group (25 participants) are recruited from Kuopio restrict lower and upper secondary schools.",[33,38],{"label":34,"type":27,"description":35,"interventionNames":36},"Study group","Adolescents diagnosed with anorexia nervosa or atypical anorexia nervosa.",[37],"Other: Observational study methods",{"label":39,"type":27,"description":40,"interventionNames":41},"Control Group","Healthy adolescents.",[37],[43],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":27},"Observational study methods","Neuroimaging, body compostion, laboratory tests and psychiatric interview in study and in control groups.",[39,34],[48],{"name":49,"affiliation":5,"role":50},"Virve Kekkonen, M.D.","PRINCIPAL_INVESTIGATOR",[52],{"name":49,"role":53,"phone":54,"phoneExt":27,"email":55},"CONTACT","+35817173311","virve.kekkonen@pshyvinvointialue.fi",{"type":50,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Virve Kekkonen","Specialist in adolescent psychiatry, clinical lecturer","100545311",false,"NCT06380257","Anorexia Nervosa and Brain in Adolescence","Inclusion Criteria:\n\nStudy group: 1) age 16-19 years, 2) BMI below 17.5, 3) diagnosis: anorexia nervosa or atypical anorexia nervosa 4) diagnosed within last two years. Inclusion criteria.\n\nControl group : 1) age 16-19 years, 2) BMI over 19.0, 3) No lifetime obesity (BMI over 30) nor eating disorder.\n\nExclusion Criteria:\n\n1\\) glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.",true,"ALL","16 Years","19 Years",{"count":69,"type":70},50,"ESTIMATED","OBSERVATIONAL","Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.",[74],"Anorexia Nervosa","NOT_YET_RECRUITING","2024-04-18",{"date":78,"type":79},"2024-04-23","ACTUAL",{"date":81,"type":70},"2024-09",{"date":83,"type":70},"2030-12",{"name":5,"class":6}]