[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611484":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":37,"studyPopulation":27,"armGroups":38,"interventions":51,"overallOfficials":27,"centralContacts":61,"locations":68,"responsibleParty":85,"collaborators":88,"id":92,"slug":27,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":27,"eligibilityCriteria":97,"healthyVolunteers":93,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":27,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":70,"whyStopped":27,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Tri-Service General Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":23,"otherOutcomes":27},[9,13,17,20],{"measure":10,"description":11,"timeFrame":12},"Nausea and vomiting","The Rhodes index of nausea, vomiting and retching (RINVR) will be used. While each item is scored from 0 to 4, the total possible score on the 8-item index is 32, with higher scores indicating greater severity.","Baseline, Week 3, Week 12, Week 18, and Week 24",{"measure":14,"description":15,"timeFrame":16},"Sleep quality","Pittsburgh Sleep Quality Index (PSQI) will be used. Each component score of the PSQI ranges from 0 to 3, with the total possible score on the 7-component index being 21. The 0-3 scale assesses sleep dysfunction and disturbance, with higher scores indicating poorer sleep quality.","Baseline, Week 12, and Week 24",{"measure":18,"description":19,"timeFrame":16},"Symptom assessment","The MD Anderson Symptom Inventory (MDASI) will be used. MDASI contains 19 items scored from 0 to 10, assessing symptom severity (13 items) and interference with daily activities (6 items). Higher scores indicate greater symptom burden.",{"measure":21,"description":22,"timeFrame":16},"Overall quality of life","The EORTC QLQ-LC13 will be used. Each item on the 13-item EORTC QLQ-LC13 is scored from 1 to 4, assessing lung cancer-specific symptoms. Higher scores indicate greater symptom severity.",[24],{"measure":25,"description":26,"timeFrame":12},"Skeletal muscle mass","Skeletal muscle mass as measured by bioelectrical impedance analysis (BIA), reported in kilograms.",null,{"allocation":29,"interventionModel":30,"interventionModelDescription":27,"primaryPurpose":31,"observationalModel":27,"timePerspective":27,"maskingInfo":32},"RANDOMIZED","PARALLEL","SUPPORTIVE_CARE",{"masking":33,"maskingDescription":27,"whoMasked":34},"DOUBLE",[35,36],"PARTICIPANT","CARE_PROVIDER","This study will test whether a nutritional supplement, Antrodia cinnamomea can help improve quality of life in lung cancer patients receiving platinum-based chemotherapy.\n\nLung cancer patients often experience side effects from chemotherapy treatment, including nausea, vomiting, sleep problems, and other symptoms that affect their daily life. Antrodia cinnamomea is a medicinal mushroom supplement that may help reduce these side effects.\n\nThe study will include lung cancer patients who are receiving platinum-based chemotherapy at Tri-Service General Hospital. Participants will be randomly assigned to one of two groups: Participants will be randomly assigned to one of two groups: half will receive capsules containing turmeric, probiotics, and Antrodia cinnamomea, and half will receive capsules containing only turmeric and probiotics. Neither participants nor doctors will know which treatment each person is receiving.\n\nAll participants will take their assigned capsules daily for 3 months. Researchers will then continue to follow participants for an additional 3 months (up to 6 months total or 24 weeks) to monitor the lasting effects of the supplement. During this time, researchers will use questionnaires to measure nausea and vomiting, sleep quality, and cancer-related symptoms. The study will compare these measurements between the two groups to see if Antrodia cinnamomea supplement helps improve quality of life.",[39,45],{"label":40,"type":41,"description":42,"interventionNames":43},"Antrodia cinnamomea plus turmeric and probiotics","EXPERIMENTAL","Participants will receive capsules containing Antrodia cinnamomea extract, turmeric, and probiotics taken orally once daily for 3 months during platinum-based chemotherapy treatment.",[44],"Dietary Supplement: Antrodia cinnamomea supplement",{"label":46,"type":47,"description":48,"interventionNames":49},"Turmeric and probiotics only","ACTIVE_COMPARATOR","Participants will receive capsules containing turmeric and probiotics (without Antrodia cinnamomea) taken orally once daily for 3 months during platinum-based chemotherapy treatment.",[50],"Dietary Supplement: Turmeric-Probiotic Group",[52,57],{"type":53,"name":54,"description":55,"armGroupLabels":56,"otherNames":27},"DIETARY_SUPPLEMENT","Antrodia cinnamomea supplement","Intervention Description:\n\nOral capsules containing Antrodia cinnamomea fruiting body extract combined with turmeric and probiotics, administered once daily for 3 months during platinum-based chemotherapy treatment. Each capsule contains standardized amounts of Antrodia cinnamomea extract, curcumin (from turmeric), and probiotic strains.",[40],{"type":53,"name":58,"description":59,"armGroupLabels":60,"otherNames":27},"Turmeric-Probiotic Group","Capsules containing turmeric and probiotics (without Antrodia cinnamomea), same dosing schedule and appearance as experimental group.",[46],[62],{"name":63,"role":64,"phone":65,"phoneExt":66,"email":67},"Chen-Liang Tsai","CONTACT","886-2-8792-3311","13899","doc10376@gmail.com",[69],{"facility":5,"status":70,"city":71,"state":27,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"RECRUITING","Taipei","114","Taiwan","TW",{"type":76,"coordinates":77},"Point",[78,79],121.52639,25.05306,{"lat":79,"lon":78},[82],{"name":63,"role":64,"phone":83,"phoneExt":66,"email":84},"886-2- 8792-3311","doc10376@gmial.com",{"type":86,"investigatorFullName":63,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"PRINCIPAL_INVESTIGATOR","Attending Physician",[89],{"name":90,"class":91},"Balay Biotechnology Corporation","UNKNOWN","100611484",false,"NCT07241182","Antrodia Cinnamomea Extract Effects on Lung Cancer Patients' Quality of Life During Chemotherapy","The Effects of Antrodia Cinnamomea Fruiting Body Extract on Quality of Life and Chemotherapy Side Effects in Patients With Lung Cancer Undergoing Platinum-Based Chemotherapy","Inclusion Criteria:\n\n* Pathologically and radio-graphically diagnosed lung cancer\n* Age greater than 18 years\n* Received platinum-based chemotherapy\n* Life expectancy of six months or longer\n\nExclusion Criteria:\n\n* Inability to comply with timely supplementation administration.\n* Within 14 days prior to trial entry, laboratory data showing abnormal liver function, abnormal kidney function\n* Within 30 days prior to trial entry, unexplained fever ≥38.5°C for 7 consecutive days or chronic diarrhea for 15 consecutive days.\n* Currently receiving hormone therapy.\n* Major cardiac disease or arrhythmia severe enough that the attending physician considers the patient unsuitable for trial participation.\n* Major neuropathy.\n* Patients with currently active acute infections.\n* Patients with known allergies\u002Fallergic reactions to the investigational product or any components in their formulations.\n* Patients currently taking supplements containing Antrodia camphorata extract.","ALL","18 Years","99 Years",{"count":102,"type":103},40,"ESTIMATED","INTERVENTIONAL",[106],"NA","This randomized trial will test whether Antrodia cinnamomea supplement improves quality of life in lung cancer patients receiving platinum-based chemotherapy.\n\nParticipants at Tri-Service General Hospital will be randomized to receive either Antrodia cinnamomea capsules or placebo for 3 months, with follow-up to 6 months (24 weeks). Primary outcomes include nausea\u002Fvomiting scores, sleep quality, quality of life, and cancer symptoms.",[109],"Lung Cancer (Diagnosis)",[111,112,113],"Chemotherapy side effects","Lung cancer","Antrodia cinnamomea","2026-01-05",{"date":116,"type":117},"2026-01-08","ACTUAL",{"date":119,"type":117},"2025-11-24",{"date":121,"type":103},"2027-09-30",{"name":5,"class":6},1]