[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616211":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":87,"collaborators":25,"id":89,"slug":25,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":90,"sex":96,"minAge":97,"maxAge":25,"enrollmentInfo":98,"targetDuration":25,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"China National Center for Cardiovascular Diseases","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Traditional off-pump coronary artery bypass grafting (Ao-SVG)","ACTIVE_COMPARATOR","Off-pump CABG with proximal saphenous vein graft (SVG) anastomoses constructed on the ascending aorta using a partial-occlusion (side-biting) clamp.",[13],"Procedure: Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)",{"label":15,"type":16,"description":17,"interventionNames":18},"Aortic no-touch coronary artery bypass grafting (RIMA-SVG)","EXPERIMENTAL","Aortic no-touch off-pump CABG in which the saphenous vein graft (SVG) is anastomosed to the right internal mammary artery (RIMA) as a composite graft, avoiding any clamping or manipulation of the ascending aorta.",[19],"Procedure: Aortic no-touch coronary artery bypass grafting (RIMA-SVG)",[21,26],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Ascending aortic no-touch CABG with saphenous vein graft (SVG) anastomosed to the right internal mammary artery (RIMA)",[15],null,{"type":22,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Lianxin Chen","CONTACT","01088322265","chenlianx1@163.com",[36,50,61,74],{"facility":37,"status":38,"city":39,"state":25,"zip":25,"country":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Fuwai Hospital Chinese Academy of Medical Sciences","RECRUITING","Beijing","China",{"type":42,"coordinates":43},"Point",[44,45],116.39723,39.9075,{"lat":45,"lon":44},[48],{"name":49,"role":32,"phone":33,"phoneExt":25,"email":34},"Chen",{"facility":51,"status":52,"city":39,"state":25,"zip":25,"country":40,"cosmosGeoPoint":53,"geoPoint":55,"contacts":56},"Peking University First Hospita","NOT_YET_RECRUITING",{"type":42,"coordinates":54},[44,45],{"lat":45,"lon":44},[57],{"name":58,"role":32,"phone":59,"phoneExt":25,"email":60},"Wang","+86 13522784537","wj0463@sina.cn",{"facility":62,"status":52,"city":63,"state":25,"zip":25,"country":40,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Qingdao Cardiovascular Hospital","Qingdao",{"type":42,"coordinates":65},[66,67],120.38042,36.06488,{"lat":67,"lon":66},[70],{"name":71,"role":32,"phone":72,"phoneExt":25,"email":73},"Feng","+86 13964265680","fengzunyi@163.com",{"facility":75,"status":52,"city":76,"state":25,"zip":25,"country":40,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen","Shenzhen",{"type":42,"coordinates":78},[79,80],114.0683,22.54554,{"lat":80,"lon":79},[83],{"name":84,"role":32,"phone":85,"phoneExt":25,"email":86},"Nie","+86 13701176101","wangsymd@126.com",{"type":88,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100616211",false,"NCT07302659","Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG","Surgical Techniques to Prevent Perioperative Neurologic Complications in Patients Undergoing Coronary Artery Bypass Grafting","PROTECT-CABG","Inclusion Criteria:\n\n* Adult patients (\\>18 years old) with multivessel coronary artery disease who are scheduled to undergo isolated off-pump coronary artery bypass grafting and who provide informed consent to participate in this study.\n\nExclusion Criteria:\n\n* Indications for cardiopulmonary bypass surgery (or no contraindications to on-pump surgery);\n* Great saphenous vein is unsuitable for use as a graft conduit;\n* Subclavian artery stenosis or occlusion, or any contraindication to the use of the internal mammary artery as a graft conduit;\n* History of previous cardiac surgery;\n* Emergency surgery;\n* Inability to apply an aortic clamp due to severe ascending aortic calcification;\n* Expected inability to tolerate MRI or contraindications to MRI (e.g., known intolerance to MRI, an implanted permanent pacemaker, or an anticipated need for permanent pacemaker implantation);\n* Inability to complete neurocognitive assessment due to language barriers or visual\u002Fhearing impairment.","ALL","18 Years",{"count":99,"type":100},380,"ESTIMATED","INTERVENTIONAL",[103],"NA","To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically:\n\nThis multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.",[106],"Coronary Artery Bypass Graft (CABG)",[108,109],"coronary artery bypass graft","Silent Brain Infarction","2026-04-09",{"date":112,"type":113},"2026-04-14","ACTUAL",{"date":115,"type":113},"2026-03-10",{"date":117,"type":100},"2028-06-30",{"name":5,"class":6},4]