[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100494209":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":53,"id":56,"slug":10,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":10,"maxAge":10,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"IRCCS Policlinico S. Donato","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Syndromic TAA",null,"Subjets with clinical or genetic diagnosis of syndromic thoracic aortic aneurysms",[13],"Device: Pulsotonometry",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-syndromic TAA","Subjets without clinical or genetic diagnosis of syndromic thoracic aortic aneurysms",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DEVICE","Pulsotonometry","Evaluation of arterial stiffness",[15,9],[25],{"name":26,"affiliation":27,"role":28},"Alessandro Pini","Cardiovascular-Gentic Centre, IRCCS Policlinico San Donato","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Alessandro Pini, MD","CONTACT","+390252774705","alessandro.pini@grupposandonato.it",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"IRCCS Policlinico San Donato","RECRUITING","San Donato Milanese","Lombardy","20097","Italy",{"type":44,"coordinates":45},"Point",[46,47],9.26838,45.41047,{"lat":47,"lon":46},[50],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":28,"investigatorFullName":26,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator",[54],{"name":55,"class":6},"Istituto Auxologico Italiano","100494209",false,"NCT05715203","Aortic Stiffness in Patients With Genetic Aortopathies","Aortic Stiffness in Patients With Genetic Aortopathies: Intervention Analysis","PULSEWAVE","Inclusion Criteria:\n\n* Subjects with AAT, either syndromic or non syndromic;\n* Signed informed consent\n\nExclusion Criteria:\n\n* Patients with early menopause and\u002For osteoporosis, rheumatic heart disease and active malignant tumours;\n* Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system;\n* Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2;\n* Pregnancy","ALL",{"count":65,"type":66},250,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are:\n\n* Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta.\n\nParticipants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.",[70,71,72],"Rare Diseases","Aortic Stiffness","Connective Tissue Defect",[74,75,76],"arterial stiffness","Ascending aortic aneurysm","pulse wave velocity","2025-09-08",{"date":79,"type":80},"2025-09-10","ACTUAL",{"date":82,"type":80},"2023-02-15",{"date":84,"type":66},"2025-12-31",{"name":5,"class":6},1]