[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573678":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":57,"collaborators":25,"id":59,"slug":25,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":25,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Transfusion algorithm based on Quantra®","EXPERIMENTAL","Patients managed using a transfusion algorithm based on Quantra®.",[13],"Biological: Transfusion algorithm based on Quantra®",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional transfusion algorithm","ACTIVE_COMPARATOR","Patients managed using a conventional transfusion algorithm.",[19],"Biological: Conventional transfusion algorithm",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","In addition to routine coagulation tests, a Quantra Qstat® analysis will be performed at baseline (before incision), at the end of native liver dissection, and after unclamping of the venous anastomoses. In the event of bleeding, additional Quantra Qstat® analyses may be conducted until bleeding control is achieved.\n\nTransfusion and administration of blood-derived medications will be guided by the results of the Quantra Qstat® analyses.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Transfusion and blood-derived medications will be guided by the results of routine coagulation tests.",[15],[30],{"name":31,"affiliation":5,"role":32},"Guillaume PORTA BONETE, Md","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","561323565","+33","porta-bonete.g@chu-toulouse.fr",[40],{"facility":41,"status":42,"city":43,"state":25,"zip":44,"country":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Toulouse University Hospital","RECRUITING","Toulouse","31059","France",{"type":47,"coordinates":48},"Point",[49,50],1.44367,43.60426,{"lat":50,"lon":49},[53,56],{"name":54,"role":35,"phone":55,"phoneExt":37,"email":38},"Guillaume PORTA BONETE","5 61 32 35 65",{"name":54,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100573678",false,"NCT06749405","Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation","QUALIVERT","Inclusion Criteria:\n\n* Patients aged 18 years or older\n* Patient with ESLD undergoing liver transplantation\n* Individuals affiliated with or beneficiaries of a social security scheme\n* Free and informed written consent obtained in writing from the patient, or where applicable from the trusted person\u002Ffamily member\u002Fclose relative\n\nNon-inclusion Criteria:\n\n* Multi-organ transplantation\n* Congenital haemostasis disorder (such as haemophilia)\n* Patient under juridical protection (persons deprived of liberty or under curatorship or guardianship or safeguard of justice)\n* Pregnant or breast-feeding woman\n* Patient already enrolled in another interventional study with primary or secondary objective of reducing perioperative bleeding or transfusion","ALL","18 Years",{"count":68,"type":69},56,"ESTIMATED","INTERVENTIONAL",[72],"NA","Liver transplantation carries a substantial risk of bleeding, making precise haemostasis control essential, although assessing coagulation remains challenging. Quantra, a bedside viscoelastic testing device using sonorheometric methods, offers an innovative approach to guiding haemostatic management during surgery. The study aims to determine whether a Quantra-guided transfusion can reduce transfusion and bleeding during liver transplantation when compared to a conventional transfusion approach.",[75],"Liver Transplantation",[77,78,79,80,81,82,83,84,85,86],"Liver transplantation","Bleeding","Blood transfusion","Quantra®","Viscoelastic test","Haemorrhagic surgery","Labile blood products","Randomized controlled trial","Coagulation","End-stage liver disease (ESLD)","2025-09-17",{"date":89,"type":90},"2025-09-22","ACTUAL",{"date":92,"type":90},"2025-03-08",{"date":94,"type":69},"2027-03",{"name":5,"class":6},1]