[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100597123":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":39,"responsibleParty":60,"collaborators":37,"id":64,"slug":37,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":37,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":37,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":37,"overallStatus":42,"whyStopped":37,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Aswan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I (Study Group)","ACTIVE_COMPARATOR","About 30 patients suffering from moderate and severe acne Vulgaris",[13],"Drug: Isotretinoin",{"label":15,"type":16,"description":17,"interventionNames":18},"Group II (Control Group)","PLACEBO_COMPARATOR","About 30 Healthy persons",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Isotretinoin","* Measure the serum levels of catestatin in patients with moderate and severe acne vulgaris versus healthy control persons.\n* Evaluate the effect of oral isotretinoin treatment on serum catestatin levels in patients with moderate and severe acne vulgaris.",[9,15],[26],"Catestatin",[28],{"name":29,"affiliation":30,"role":31},"Moustafa Adam Ali El Taieb, Professor","Dermatology, Venereology and Andrology. Faculty of Medicine,Aswan University","STUDY_CHAIR",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Mona Zakaria Mohamed, MSc","CONTACT","+201142550119",null,"mona1704213@aswu.edu.eg",[40],{"facility":41,"status":42,"city":43,"state":37,"zip":37,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Aswan Unuversity Hospital","RECRUITING","Aswān","Egypt",{"type":46,"coordinates":47},"Point",[48,49],32.89942,24.09082,{"lat":49,"lon":48},[52,56],{"name":53,"role":35,"phone":54,"phoneExt":37,"email":55},"Mahmoud Ahmed Ali, M.D","+201002364902","dr.mahmoudali@aswu.edu.eg",{"name":57,"role":35,"phone":58,"phoneExt":37,"email":59},"Mohamed Amer Ahmed Abdellatif, M.D","+201060394083","mohammed.abdellatif@aswu.edu.eg",{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"PRINCIPAL_INVESTIGATOR","Mona Zakaria Mohamed","Resident of Dermatology, at Faculty of medicine","100597123",false,"NCT07054398","Assessment of Serum Catestatin Level in Acne Vulgaris Patients","Assessment of Serum Catestatin Level in Acne Vulgaris Patients Before and After Treatment With Oral Isotretinoin","Inclusion Criteria:\n\n* Healthy persons of both sexes with moderate and severe acne.\n\nExclusion Criteria:\n\n* Pregnant and lactating women.\n* Immunocompromised patients.\n* Severe anemia.\n* History of chronic liver disease.\n* Hyperlipidemia\n* Non-inflammatory acne conditions.\n* History of neurologic disorders.\n* History of neoplastic disorders.\n* History of cardiac disease.\n* History of systemic acne treatment for at least 4 weeks prior to inclusion and no topical treatments for at least 2 weeks.\n* Cases with known hypersensitivity reaction to isotretinoin.",true,"ALL","18 Years","40 Years",{"count":75,"type":76},60,"ESTIMATED","INTERVENTIONAL",[79],"NA","Acne vulgaris is a persistent inflammatory condition of the pilosebaceous unit, affecting 85% of people between the ages of 12 and 24, it is regarded as one of the most common diseases in teenagers and young adults.\n\nCatestatin, a peptide derived from chromogranin A (CgA), was first discovered in 1997 as an acute nicotinic-cholinergic antagonist. Later, it was determined that CST is a pleiotropic hormone.",[82],"Acne Vulgaris","2025-06-27",{"date":85,"type":86},"2025-07-08","ACTUAL",{"date":88,"type":86},"2025-01-10",{"date":90,"type":76},"2026-01-10",{"name":5,"class":6},1]