[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100472168":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":24,"responsibleParty":37,"collaborators":41,"id":47,"slug":10,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Cagliari","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Thyroid carcinoma",null,"Patients with indeterminate thyroid nodule and pathological diagnosis of thyroid carcinoma",[13],"Diagnostic Test: Multiomic analyses of blood and surgical specimens",{"label":15,"type":10,"description":16,"interventionNames":17},"Follicular adenoma","Patients with indeterminate thyroid nodule and pathological diagnosis of follicular adenoma",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Multiomic analyses of blood and surgical specimens","The following items will be evaluated:\n\n* cell free dna length and integrity\n* presence or absence of SNPs in cfDNA and in DNA extracted from surgical samples\n* qualitative and quantitative evaluation of serum and surgical specimens proteome (proteomics)",[15,9],[25],{"facility":26,"status":10,"city":27,"state":28,"zip":29,"country":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":10},"AOU Cagliari","Cagliari","CA","09100","Italy",{"type":32,"coordinates":33},"Point",[34,35],9.11917,39.23054,{"lat":35,"lon":34},{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Fabio Medas","Associate Professor",[42,45],{"name":43,"class":44},"Prof. Pietro Giorgio Calò","UNKNOWN",{"name":46,"class":44},"Dott. Gian Luigi Canu","100472168",false,"NCT05428371","Assessment the Cancer Risk of Indeterminate Thyroid Nodules Through Integration of Clinical, Ultrasonographic and Multiomic Features","A Novel, Multimodal, Machine-learning Grounded Approach to Assess the Oncological Risk of Indeterminate Thyroid Nodules","THYOMICS","Inclusion Criteria:\n\n* Patients with indeterminate thyroid nodules (Class III and Class IV according to Bethesda Classification of thyroid nodules)\n\nExclusion Criteria:\n\n* Patients with concomitant thyroid nodules of Bethesda Class V or Class VI\n* Patients with preoperative diagnosis of lymph node metastases of central or lateral neck compartment\n* Patients with distant metastases","ALL","18 Years",{"count":57,"type":58},256,"ESTIMATED","OBSERVATIONAL","Indeterminate thyroid nodules have a mild risk of malignancy (15-30%). The aim of our study is to individuate new biomarkers of thyroid carcinoma through multiomic analyses of blood samples and of specimen samples of patients with indeterminate thyroid nodules.",[62,63],"Thyroid Nodule","Thyroid Cancer",[9,65,66,67,68],"Indeterminate thyroid nodule","Genomics","Proteomics","Metabolomics","NOT_YET_RECRUITING","2022-06-16",{"date":72,"type":73},"2022-06-23","ACTUAL",{"date":75,"type":58},"2023-01-01",{"date":77,"type":58},"2027-12-31",{"name":5,"class":6},1]