[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100514162":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":59,"collaborators":10,"id":63,"slug":10,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Chongqing Medical University","OTHER",[8,12,17,20],{"label":9,"type":10,"description":11,"interventionNames":10},"Non-MAFLD group",null,"controlled attenuation parameter\\\u003C274 dB\u002Fm",{"label":13,"type":10,"description":14,"interventionNames":15},"MAFLD group","controlled attenuation parameter ≥ 274 dB\u002Fm",[16],"Other: high-sensitivity C-reactive protein to albumin ratio",{"label":18,"type":10,"description":19,"interventionNames":10},"Non-fibrosis group","liver stiffness measurement \\\u003C 8.2 kPa",{"label":21,"type":10,"description":22,"interventionNames":23},"Fibrosis group","liver stiffness measurement ≥ 8.2 kPa",[16],[25],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"high-sensitivity C-reactive protein to albumin ratio","High-sensitivity C-reactive protein to albumin ratio is an inflammatory indicator which can make a determination of disease severity.",[21,13],[30],{"name":31,"affiliation":32,"role":33},"Tingqiu Wang, Bachelor","The Second Affiliated Hospital of Chongqing Medical University","STUDY_DIRECTOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":10,"email":38},"CONTACT","+8617815370539","w857683014@163.com",{"name":40,"role":36,"phone":41,"phoneExt":10,"email":42},"Zhigang Luo, Master","+8618989126596","306395@hospital.cqmu.edu.cn",[44],{"facility":32,"status":45,"city":46,"state":47,"zip":48,"country":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Chongqing","Chongqing Municipality","400000","China",{"type":51,"coordinates":52},"Point",[53,54],106.55771,29.56026,{"lat":54,"lon":53},[57],{"name":31,"role":36,"phone":58,"phoneExt":10,"email":38},"17815370539",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Tingqiu Wang","Principal Investigator","100514162",false,"NCT05974904","Association of HsCAR with MAFLD and Liver Fibrosis: a Cross-sectional Study","Association of High-sensitivity C-reactive Protein to Albumin Ratio with Metabolic Dysfunction-associated Fatty Liver Disease and Liver Fibrosis: a Cross-sectional Study","Inclusion Criteria:\n\n* Total participants from NHANES 2017-2020\n* Participants diagnosed with MAFLD. Metabolic dysfunction-associated fatty liver disease (MAFLD) is the term used to describe hepatic steatosis in the presence of metabolic abnormalities, excess weight, obesity, or type 2 diabetic mellitus.\n\n  1. Diagnosis of diabetes mellitus: (1) taking glucose-lowering drugs; (2) HbA1c ≥ 6.5% (48 mmol\u002Fmol); (3) fasting plasma glucose ≥ 7.0 mmol\u002FL (126 mg\u002FdL); (4) 2-hour plasma glucose (2hPG) ≥ 11.1 mmol\u002FL (200 mg\u002FdL).\n  2. Overweight or obesity: defined as BMI≥25 kg\u002Fm2 in Caucasians or BMI≥23 kg\u002Fm2 in Asians\n  3. If presence of at least two metabolic risk abnormalities:\n\n     * Waist circumference≥102\u002F88 cm in Caucasian men and women (or≥90\u002F80 cm in Asian men and women)\n     * Blood pressure≥130\u002F85 mmHg or specific drug treatment\n     * Plasma triglycerides≥150 mg\u002Fdl (≥1.70 mmol\u002FL) or specific drug treatment\n     * Plasma HDL-cholesterol \\\u003C40 mg\u002Fdl (\\\u003C1.0 mmol\u002FL) for men and \\\u003C50 mg\u002Fdl (\\\u003C1.3 mmol\u002FL) for women or specific drug treatment\n     * Prediabetes (i.e., fasting glucose levels 100 to 125 mg\u002Fdl \\[5.6 to 6.9 mmol\u002FL\\], or 2-hour post-load glucose levels 140 to 199 mg\u002Fdl \\[7.8 to 11.0 mmol\\] or HbA1c 5.7% to 6.4% \\[39 to 47 mmol\u002Fmol\\])\n     * Homeostasis model assessment of insulin resistance score≥2.5\n     * Plasma high-sensitivity C-reactive protein level \\>2 mg\u002FL\n\nExclusion Criteria:\n\n* Liver ultrasound data not available\n* participants without complete clinical data\n* participants under 18 years old\n* participants with cancer.","ALL","18 Years","90 Years",{"count":73,"type":74},7000,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to investigate the associations between a novel inflammatory marker, high sensitivity C-reactiveprotein to albumin ratio (hsCAR), and steatosis and fibrosis of metabolic dysfunction-associated fatty liver disease (MAFLD).\n\nThe main question\\[s\\] it aims to answer are:\n\n\\[question 1\\] Can hsCAR serve as a clinical indicator to determine whether a patient has MAFD? \\[question 2\\] Can hsCAR determine whether MAFLD patients are complicated with liver fibrosis?",[78,79,80],"Metabolic Dysfunction-associated Fatty Liver Disease","Hepatic Steatosis","Liver Fibrosis",[26,82,83,84,85,86],"metabolic dysfunction-associated fatty liver disease","National Health and Nutrition Examination Survey","control attenuation parameter","liver stiffness measurement","inflammation","2025-02-10",{"date":89,"type":90},"2025-02-12","ACTUAL",{"date":92,"type":90},"2023-07-18",{"date":94,"type":74},"2026-12-28",{"name":5,"class":6},1]