Health Trials

About this trial

The aim of this study is to evaluate the relationship between periodontal status and salivary levels of the inflammasomes NOD-like receptor family, pyrin domain containing 3 (NLRP-3), NOD-like receptor family, pyrin domain containing 6 (NLRP-6), NOD-like receptor family, pyrin domain containing 12 (NLRP-12), NOD-like receptor family, CARD domain containing 5 (NLRC-5), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10). Furthermore, this study aims to investigate whether the salivary levels of these inflammasomes may serve as potential diagnostic biomarkers for distinguishing individuals with periodontitis from those without. In addition, the potential role of smoking in modulating the relationship between periodontal status and salivary inflammasome levels will also be explored.

Eligibility criteria

Qualifiers

systemically healthy,

clinical diagnosis of periodontitis,

clinical diagnosis of periodontal health

Disqualifiers

history of regular use of systemic antibiotics, anti-inflammatory, or antioxidant drugs (previous 6 months);

nonsurgical periodontal treatment (previous 6 months);

surgical periodontal treatment (previous 12 months);

presence of <20 teeth;

Trial design

Treatments tested in this trial

  • Periodontal examinations
  • Collection of saliva samples

Treatment groups

116 Participants
are divided into 4 treatment groups

Locations

1
Uskudar University, Faculty of Dentistry Istanbul Turkey (Türkiye)

Sponsors and collaborators

Uskudar University

Lead sponsor

Source ClinicalTrials.gov