[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555929":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":27,"overallOfficials":35,"centralContacts":40,"locations":47,"responsibleParty":70,"collaborators":17,"id":73,"slug":17,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":17,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":85,"studyType":86,"phases":17,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":50,"whyStopped":17,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Mansoura University Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":17,"otherOutcomes":17},[9,13],{"measure":10,"description":11,"timeFrame":12},"Atopy in chronic obstructive pulmonary disease patients","Total IgE (mg\u002Fdl) and ) will be assessed in chronic obstructive pulmonary disease patients","6 months",{"measure":14,"description":15,"timeFrame":16},"Chronic obstructive pulmonary disease patients","Blood eosinophil count (%) will be assessed in chronic obstructive pulmonary disease patients","2 months",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"CASE_CROSSOVER","PROSPECTIVE","Chronic Obstructive Pulmonary Disease(COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production and\u002For exacerbations) due to abnormalities of airways (bronchitis, bronchiolitis) and\u002For alveoli (emphysema) that cause persistent, often progressive, airflow obstruction.\n\nThe presence of non-fully reversible airflow obstruction (FEV1\u002FFVC \\\u003C 0.7 post-bronchodilation) measured by spirometry confirms the diagnosis of COPD Inflammation of the bronchial wall is characterized by the presence of neutrophils and macrophages and by increased concentrations of IL-8 and Th1 cytokines, as well as by a proteinase \u002Fantiproteinase imbalance, and this could explain the poorer response to inhaled corticosteroids (ICs) seen in COPD.\n\nAsthma may also be a risk factor for the development of chronic airflow obstruction and COPD and Epidemiological Study of Airway Obstructive Disease, adults diagnosed of asthma were found to have a 12-fold higher risk of acquiring COPD over time compared to those without asthma, after adjusting for smoking.\n\nAlthough both COPD and asthma are associated with chronic inflammation of the respiratory tract, there are differences in the inflammatory cells and mediators involved in the two diseases, some patients with COPD have an inflammatory pattern with increased eosinophils cells, similar to that of asthma.\n\nWhen there is diagnostic of Asthma and COPD overlap (ACO) uncertainty, an elevated total serum immunoglobulin E (IgE; \\>100 international units\u002FmL), elevated peripheral blood eosinophil count (\\>300 cells\u002FmicroL), and evidence of allergic disease (eg, skin testing or immunoassays for perennial allergen sensitivity) may point a clinician to asthma or Asthma - COPD overlap (ACO). Elevated sputum eosinophil counts, if available, are more common in asthma or ACO than COPD The Dutch hypothesis suggests that atopy and bronchial hyper-responsiveness , which are important markers of asthma, can be involved in the pathogenesis of COPD, although there is no clear evidence regarding the frequency of atopy (including asthma), Allergic rhinitis (AR), eczema, or increased IgE levels in patients with COPD, because most studies have involved small samples and limited evaluation of atopy.","Adults aged 40-70 years diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2024 criteria",[24],{"label":14,"type":17,"description":22,"interventionNames":25},[26],"Diagnostic Test: Skin prick test",[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DIAGNOSTIC_TEST","Skin prick test","Skin Prick Test (SPT): Common allergens including pollen, dust mites, Pet dander and mold.\n\nSerum IgE Levels: Total IgE Peripheral blood eosinophil was defined as an eosinophil count ≥ 5%, Quality of Life Assessment: COPD Assessment Test (CAT)",[14],[34],"Total IgE",[36],{"name":37,"affiliation":38,"role":39},"Mohamed AbdElmoniem, lecturer","Lecturer of chest medicine Faculty of medicine Mansoura university","PRINCIPAL_INVESTIGATOR",[41,45],{"name":37,"role":42,"phone":43,"phoneExt":17,"email":44},"CONTACT","01014008473","dr.m1993@mans.edu.eg",{"name":46,"role":42,"phone":17,"phoneExt":17,"email":17},"Taha Abdelgawad, Professor",[48],{"facility":49,"status":50,"city":51,"state":17,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Mohamed AbdElmoniem","RECRUITING","Al Mansurah","35516","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.38069,31.03637,{"lat":59,"lon":58},[62,63,65,68],{"name":49,"role":42,"phone":43,"phoneExt":17,"email":44},{"name":64,"role":42,"phone":17,"phoneExt":17,"email":17},"Taha Abdelgawad",{"name":66,"role":67,"phone":17,"phoneExt":17,"email":17},"Taha Taha Abd El Gawad, Professor","SUB_INVESTIGATOR",{"name":69,"role":67,"phone":17,"phoneExt":17,"email":17},"Tamer Awad Elsayed, Lecturer",{"type":39,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":17,"oldOrganization":17},"Mohamed Abd Elmoniem Mohamed","Lecturer of chest medicine","100555929",false,"NCT06518473","Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients","The Relation Between Atopy and Frequency of Exacerbation in Chronic Obstructive Pulmonary Disease Patients","Inclusion Criteria:\n\n* Adults aged 40-70 years diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2024 criteria\n\nExclusion Criteria:\n\n* Patients with known allergic diseases before enrollment\n* Patients with associated other chronic respiratory disorders\n* Patients with significant comorbidities that could influence respiratory function.\n* Recent respiratory infections or use of systemic corticosteroids within the last month before enrollment.","ALL","40 Years","70 Years",{"count":83,"type":84},50,"ESTIMATED","6 Months","OBSERVATIONAL","Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production and\u002For exacerbations) due to abnormalities of airways (bronchitis, bronchiolitis) and\u002For alveoli (emphysema) that cause persistent, often progressive, airflow obstruction.\n\nThe presence of non-fully reversible airflow obstruction (FEV1\u002FFVC \\\u003C 0.7 post-bronchodilation) measured by spirometry confirms the diagnosis of COPD",[89],"Chronic Obstructive Pulmonary Disease",[91,92,93],"atopy","frequency of exacerbation","chronic obstructive pulmonary disease","2025-07-30",{"date":96,"type":97},"2025-08-03","ACTUAL",{"date":99,"type":97},"2024-07-14",{"date":101,"type":84},"2025-12-15",{"name":5,"class":6},1]