Autoantibodies Against-nephrin in Idiopathic Nephrotic Syndrome
ConditionNephrotic Syndrome
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMario Negri Institute for Pharmacological Research
About this trial
This retrospective study is aimed at evaluating the levels of circulating anti-nephrin autoantibodies in patients with INS, including those with MCD/FSGS and in patients who have experienced relapse of FSGS post-transplant, compared to those of a control group of patients with nephrotic syndrome due to primary membranous nephropathy (MN).
Eligibility criteria
Qualifiers
Adult (>18 years) males and females
Patients with biopsy-proven idiopathic MCD or FSGS (cases)
Patients with biopsy-proven idiopathic membranous nephropathy (controls)
Patients who provided consent to store their samples in the certified CRB biobank
Disqualifiers
Reasonable possibility of a secondary cause of NS (for cases) or MN (for controls) at time of blood collections
Active viral or bacterial infections at time of blood collections
Trial design
Treatments tested in this trial
- In-house ELISA, and ELISA kits from "DBA Italy" (Abbexa).
Treatment groups
100 Participants
are divided into 2 treatment groupsLocations
1Clinical Research Center for Rare Disease Aldo e Cele Daccò24020, RanicaBG, Italy
Sponsors and collaborators
Mario Negri Institute for Pharmacological Research
Lead sponsor
Source ClinicalTrials.gov