About this trial

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.

Eligibility criteria

Qualifiers

autonomic neuropathy

Postural orthostatic tachycardia syndrome

hypermobile or classical Ehlers Danlos syndromes

Chronic fatigue syndrome, mast cell activation syndrome and/or PostCOVID

Disqualifiers

pregnancy

Pacemaker or Deep brain Stimulation

sensory or motor Polyneuropathy

neurodegenerative disease

Trial design

Treatments tested in this trial

  • No intervention planned, but all patients get our standart treatment

Treatment groups

200 Participants
are divided into 5 treatment groups

Locations

1
University clinic RWTH Aachen52074, AachenNorth Rhine-Westphalia, Germany

Sponsors and collaborators

RWTH Aachen University

Lead sponsor

DLR German Aerospace Center

Collaborator