[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100452656":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":30,"studyPopulation":23,"armGroups":31,"interventions":38,"overallOfficials":42,"centralContacts":46,"locations":51,"responsibleParty":69,"collaborators":23,"id":72,"slug":23,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":23,"studyType":85,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":54,"whyStopped":23,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"UConn Health","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":23},[9],{"measure":10,"description":11,"timeFrame":12},"Changes in KCCQ-23 score","Kansa city cardiomyopathy questionnaire (KCCQ-23)- self-administered, 23-item. questionnaire that quantifies physical limitations, symptoms, self-efficacy, social interference and quality of life. Scores are transformed to a range of 0-100, where higher scores reflect better health status.","Baseline and after 4 weeks of beta blocker discontinuation",[14,17,20],{"measure":15,"description":16,"timeFrame":12},"Changes in cardiac mechanics by echocardiography","Echocardiographic E\u002Fe' ratio",{"measure":18,"description":19,"timeFrame":12},"Changes in biomarker","changes from baseline in BNP level (pg\u002FmL) after 4 weeks of beta blocker discontinuation",{"measure":21,"description":22,"timeFrame":12},"6 minute walk test","The distance (meters) covered over a time of 6 minutes. A greater distance indicates a better exercise capacity.",null,{"allocation":25,"interventionModel":26,"interventionModelDescription":23,"primaryPurpose":27,"observationalModel":23,"timePerspective":23,"maskingInfo":28},"NA","SINGLE_GROUP","TREATMENT",{"masking":29,"maskingDescription":23,"whoMasked":23},"NONE","This is a prospective pilot study to evaluate changes before and 4 weeks(+\u002F- 1 week) after beta-blocker withdrawal in 30 HFpEF patients. The study involves 2 visits that are 4 weeks apart. The first study visit will occur at a standard of care clinic visit and the second visit will be a research visit to fill out questionnaires and perform the limited echocardiogram. No long term follow up beyond the 2nd visit.",[32],{"label":33,"type":34,"description":35,"interventionNames":36},"HFpEF patients","EXPERIMENTAL","HFpEF patient who are currently taking beta blockers",[37],"Other: beta blocker discontinuation",[39],{"type":6,"name":40,"description":40,"armGroupLabels":41,"otherNames":23},"beta blocker discontinuation",[33],[43],{"name":44,"affiliation":5,"role":45},"Kai Chen, MD,PhD","PRINCIPAL_INVESTIGATOR",[47],{"name":44,"role":48,"phone":49,"phoneExt":23,"email":50},"CONTACT","860-679-3343","kachen@uchc.edu",[52],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"UConn Health \u002F John Dempsey Hospital","RECRUITING","Farmington","Connecticut","06030","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-72.83204,41.71982,{"lat":64,"lon":63},[67],{"name":68,"role":48,"phone":49,"phoneExt":23,"email":50},"Kai Chen, MD, PhD",{"type":45,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Christopher Pickett","Associate Professor","100452656",false,"NCT05174351","Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction","Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients With Heart Failure With Preserved Ejection Fraction","HFpEF-BB","Inclusion Criteria:\n\n* Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100\n* N=30 (Target: 30).\n* Age: 50 \\~ 80 years.\n* ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.\n* Chronic loop diuretic use\n* Currently on beta-blocker\n\nExclusion Criteria:\n\n* Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.\n* Heart rate \\> 100 bpm\n* Recent hospitalization due to HF within 3 months\n* Non-English speaker","ALL","50 Years","80 Years",{"count":83,"type":84},30,"ESTIMATED","INTERVENTIONAL",[25],"This is a prospective pilot study to evaluate changes before and 4 weeks after beta-blocker withdrawal in 30 HFpEF patients.",[89],"Heart Failure With Preserved Ejection Fraction",[91,92,93,94],"HFpEF","Beta-blocker","echocardiogram","6MWT","2025-09-23",{"date":97,"type":98},"2025-09-29","ACTUAL",{"date":100,"type":98},"2021-12-20",{"date":102,"type":84},"2027-11-01",{"name":5,"class":6},1]