[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100540220":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":23,"studyPopulation":27,"armGroups":28,"interventions":38,"overallOfficials":44,"centralContacts":48,"locations":58,"responsibleParty":75,"collaborators":23,"id":77,"slug":23,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":23,"eligibilityCriteria":81,"healthyVolunteers":78,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":23,"studyType":88,"phases":23,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":60,"whyStopped":23,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Endeavor Health","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":23},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Inter - rater reliability of assessing placental blood flow by arterial spin labeling (ASL)","Evaluated using a two-way mixed intraclass correlation coefficient for consistency","6 weeks after the delivery",{"measure":14,"description":15,"timeFrame":12},"Mean placental perfusion in second and third trimester","The mean global placental perfusion of second and third-trimester placentas among participants with obesity (Body Mass Index measured in kg\u002Fm\\^2, calculated using weight in kilograms and height in meters) as compared to those with a normal weight (kilograms) before pregnancy will be evaluated.",{"measure":17,"description":18,"timeFrame":12},"Mean R2* relaxation rates in second and third trimester","the Mean R2\\* relaxation rates will be used to correlate the global placental perfusion of second and third trimester placentas with measurements of placental oxygenation.",[20],{"measure":21,"description":22,"timeFrame":12},"Perinatal outcomes including hypertensive disorders of pregnancy, gestational diabetes, preterm birth, small for gestational age, NICU admission, and stillbirth.","The prevalence and incidence of outcomes such as hypertensive disorders of pregnancy, gestational diabetes, preterm birth, small for gestational age, NICU (Neonatal Intensive Care Unit) admission, stillbirth will be assessed.",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":26,"maskingInfo":23},"COHORT","PROSPECTIVE","Pregnant people at 20-24 weeks gestation. 15 obese (OB) women and 15 normal weight (NW) will be recruited to participate in the study.\n\nOB is defined as pre-pregnancy body mass index greater than or equal to 30 kg\u002Fm2, and NW is defined as pre-pregnancy body mass index between 18.5-24.9 kg\u002Fm2 without comorbidities.",[29,34],{"label":30,"type":23,"description":31,"interventionNames":32},"Normal Weight","Body Mass Index (BMI) 18.5-24.9 kg\u002Fm\\^2",[33],"Diagnostic Test: functional Magnetic Resonance Imaging (fMRI)",{"label":35,"type":23,"description":36,"interventionNames":37},"Obese","Pre-pregnancy Body Mass Index (BMI) ≥ 30.0 kg\u002Fm\\^2",[33],[39],{"type":40,"name":41,"description":42,"armGroupLabels":43,"otherNames":23},"DIAGNOSTIC_TEST","functional Magnetic Resonance Imaging (fMRI)","Participants will undergo a functional Magnetic Resonance Imaging (fMRI) using arterial spin labeling (ASL) and other Magnetic Resonance (MR) sequences",[30,35],[45],{"name":46,"affiliation":5,"role":47},"Caitlin MacGregor","PRINCIPAL_INVESTIGATOR",[49,54],{"name":50,"role":51,"phone":52,"phoneExt":23,"email":53},"Alexandra Mangus","CONTACT","(847) 570-2243","alexandra.mangus@endeavorhealth.org",{"name":55,"role":51,"phone":56,"phoneExt":23,"email":57},"Caitlin A MacGregor, MD","(847) 570-4729","caitlin.macgregor@endeavorhealth.org",[59],{"facility":5,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"RECRUITING","Evanston","Illinois","60201","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-87.69006,42.04114,{"lat":70,"lon":69},[73],{"name":74,"role":51,"phone":23,"phoneExt":23,"email":57},"Caitlin MacGregor, MD",{"type":47,"investigatorFullName":46,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Physician, Fpa","100540220",false,"NCT06314009","Beyond MARS: Magnetic Resonance Study: A Novel Assessment of Placental Perfusion During Pregnancy","Inclusion Criteria:\n\n* Singleton pregnancy, less than 24 weeks gestation\n* Pre-pregnancy BMI between 18.5 - 24.9kg\u002Fm2 or ≥30kg\u002Fm2\n\nExclusion Criteria:\n\n* Asthma on controller medication\n* Autoimmune Conditions\n* Chronic Hypertension\n* Claustrophobia\n* Congenital Anomaly\n* Pregestational Diabetes\n* History of Bariatric Surgery\n* HIV\n* Ineligible for MRI (incompatible implanted medical device)\n* Multifetal Gestation\n* Smoking during pregnancy","FEMALE","18 Years","60 Years",{"count":86,"type":87},30,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to evaluate the flow of oxygen and blood necessary for nutrient transfer across the placenta during the second and third trimesters in pregnancy in women who are obese before pregnancy compared to women who have an average weight before pregnancy.\n\nThis study will evaluate blood flow across the placenta by functional Magnetic Resonance Imaging (fMRI). The investigators hypothesize that there will be differences in placental oxygenation and blood flow among women with obesity as compared to those with normal weight.\n\nParticipants will be asked to complete:\n\n* MRI in the second trimester (20-24 weeks)\n* MRI in the third trimester (30-34 weeks)",[91],"Pregnancy",[93,94,95,96],"Placenta","MRI","BMI","Weight","2026-03-13",{"date":99,"type":100},"2026-03-16","ACTUAL",{"date":102,"type":100},"2024-05-09",{"date":104,"type":87},"2026-12",{"name":5,"class":6},1]