[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100342913":3},{"organization":4,"outcomesModule":7,"designInfo":29,"detailedDescription":33,"studyPopulation":34,"armGroups":30,"interventions":30,"overallOfficials":35,"centralContacts":40,"locations":45,"responsibleParty":68,"collaborators":72,"id":75,"slug":30,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":30,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":30,"maxAge":30,"enrollmentInfo":82,"targetDuration":30,"studyType":85,"phases":30,"briefSummary":86,"conditions":87,"keywords":30,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Shantou University Medical College","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":21,"otherOutcomes":25},[9,13,17],{"measure":10,"description":11,"timeFrame":12},"Expression status of biomarkers and their dynamic changes during treatment and follow-up","Expression status of biomarkers and their dynamic changes in patients' biological specimens through the course of treatment and during follow-up as assessed by a variety of means, including RNA-seq, DNA-seq, RT-qPCR, IHC, WB and ELISA.","From the date of enrollment until the date of disease progression, assessed up to 3 years",{"measure":14,"description":15,"timeFrame":16},"Tumor short-term response to therapeutics","For patients treated with radiotherapy, shortly after the completion of treatment, the short-term response was assessed by using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST1.1) .","Within 1 month after the completion of radiotherapy",{"measure":18,"description":19,"timeFrame":20},"Tumor long-term response to therapeutics","For patients treated with radiotherapy, tumor response was assessed by using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST1.1) .","up to 3 years of follow-up",[22],{"measure":23,"description":24,"timeFrame":20},"Disease-specific survival","The tumor disease-specific survival of patients",[26],{"measure":27,"description":28,"timeFrame":20},"Overall survival","The overall survival of patients",{"allocation":30,"interventionModel":30,"interventionModelDescription":30,"primaryPurpose":30,"observationalModel":31,"timePerspective":32,"maskingInfo":30},null,"COHORT","PROSPECTIVE","Patients pathologically confirmed with solid tumors that requires radiotherapy or surgery will be recruited to this study. Tumor samples were obtained from patients underwent surgery to establish the baseline status of biomarker assessed. Peripheral and microbiota will also be collected before and after surgery. For patients undergoing radiotherapy, tumor biopsy as well as collection of blood samples and microbiota will be performed during the course of treatment. These biological specimens will be used for assessment of tumor phenotypes and for exploration of potential biomarkers that could predict the tumor response to therapeutics and prognsis in patients with solid tumors.","Patients proven diagnosis of solid tumors and will have radiotherapy as part of their therapeutic regimens or will undergo surgery in Cancer Hospital of Shantou University Medical College.",[36],{"name":37,"affiliation":38,"role":39},"Chuangzhen Chen, MD","Affiliated Cancer Hospital of Shantou University Medical College","PRINCIPAL_INVESTIGATOR",[41],{"name":37,"role":42,"phone":43,"phoneExt":30,"email":44},"CONTACT","+86 13923995569","stccz@139.com",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Cancer Hospital, Shantou University Medical College","RECRUITING","Shantou","Guangdong","515031","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.67876,23.35489,{"lat":58,"lon":57},[61,63,67],{"name":37,"role":42,"phone":62,"phoneExt":30,"email":44},"86-13923995569",{"name":64,"role":42,"phone":65,"phoneExt":30,"email":66},"Jianzhou Chen, MD","86-13417049908","cjzeoeo@gmail.com",{"name":37,"role":39,"phone":30,"phoneExt":30,"email":30},{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Chuangzhen Chen","Deputy Director, Department of Radiation Oncology",[73],{"name":74,"class":6},"University of Oxford","100342913",false,"NCT03744819","Biomarkers for Prediction of Tumor Response to Radiotherapy","Exploration of Potential Biomarkers to Predict Tumor Response to Radiotherapy in Patients With Solid Tumors","Inclusion Criteria:\n\n* Pathological proven diagnosis of solid tumors\n* Tumor accessible for biopsy during the course of radiotherapy or tumor samples could be obtained via surgery\n* Patient must provide study-specific informed consent prior to study entry\n\nExclusion Criteria:\n\n* History of autoimmune diseases\n* History of immunotherapy\n* Prior radiation therapy that would result in overlap of planned radiation therapy fields\n* Will receive immunotherapy during the course of radiotherapy\n* Contraindications for biopsy, such as high bleeding risk","ALL",{"count":83,"type":84},100,"ESTIMATED","OBSERVATIONAL","This study aims to explore potential biomarkers for prediction of therapeutic outcomes in patients with solid tumors after radiotherapy",[88],"Solid Tumors","2024-02-03",{"date":91,"type":92},"2024-02-06","ACTUAL",{"date":94,"type":92},"2018-10-29",{"date":96,"type":84},"2026-11-30",{"name":70,"class":6},1]