[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606983":3},{"organization":4,"outcomesModule":7,"designInfo":21,"detailedDescription":20,"studyPopulation":24,"armGroups":25,"interventions":37,"overallOfficials":51,"centralContacts":56,"locations":64,"responsibleParty":83,"collaborators":20,"id":85,"slug":20,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":20,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":20,"studyType":98,"phases":20,"briefSummary":99,"conditions":100,"keywords":101,"overallStatus":107,"whyStopped":20,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Region Stockholm","OTHER_GOV",{"primaryOutcomes":8,"secondaryOutcomes":16,"otherOutcomes":20},[9,13],{"measure":10,"description":11,"timeFrame":12},"Relative expression levels (e.g., fold change, normalized intensity, or concentration in pg\u002FmL\u002Fng\u002FmL depending on biomarker assay)","Evaluation of the expression levels of selected biomarkers in endometrial fluid samples from patients with moderate to severe endometriosis compared to healthy controls.","2 years",{"measure":14,"description":15,"timeFrame":12},"Percentage of blastoids successfully implanted in vitro (% implantation rate)","Evaluation of the implantation efficiency of blastoids in vitro (endometrial organoids) under controlled laboratory conditions.",[17],{"measure":18,"description":19,"timeFrame":12},"Relative expression levels (e.g., concentration in pg\u002FmL, ng\u002FmL, or fold change depending on assay)","Assessment of biomarker expression levels in follicular fluid samples from follicles in different distances from endometriomas in patients with severe endometriosis.",null,{"allocation":20,"interventionModel":20,"interventionModelDescription":20,"primaryPurpose":20,"observationalModel":22,"timePerspective":23,"maskingInfo":20},"COHORT","PROSPECTIVE","We are going to recruit 30 patients who undergo fertility preservation or fertility treatment before endometriosis surgery in the Reproductive Medicine Clinic in Karolinska University Hospital. Our patients are diagnosed with stage III\u002FIV endometriosis according to rASRM staging by using ultrasound. The control group will consist of 60 healthy women without endometriosis signs in the ultrasound who present to our clinic as oocyte donors or for fertility treatment because of male factor or pregenetic testing for genetic diseases of the partner",[26,33],{"label":27,"type":20,"description":28,"interventionNames":29},"Endometriosis","Moderate\u002Fsevere endometriosis",[30,31,32],"Diagnostic Test: Endometrial fluid","Diagnostic Test: Endometrial biopsy","Diagnostic Test: Follicular fluid",{"label":34,"type":20,"description":35,"interventionNames":36},"Controls","Healthy women undergoing oocyte pick up",[30,31],[38,43,47],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":20},"DIAGNOSTIC_TEST","Endometrial fluid","Endometrial fluid collection in the day of OPU",[34,27],{"type":39,"name":44,"description":45,"armGroupLabels":46,"otherNames":20},"Endometrial biopsy","Endometrial biopsy on the OPU day, Pipelle",[34,27],{"type":39,"name":48,"description":49,"armGroupLabels":50,"otherNames":20},"Follicular fluid","Follicular fluid sampling on the OPU day",[27],[52],{"name":53,"affiliation":54,"role":55},"Kenny Rodriguez-Wallberg, Professor","Onk\u002FPat Karolinska Institute","PRINCIPAL_INVESTIGATOR",[57,62],{"name":58,"role":59,"phone":60,"phoneExt":20,"email":61},"Anastasia Drakou, MSc, PhD student","CONTACT","+46735500118","anastasiadrakou1989@gmail.com",{"name":53,"role":59,"phone":20,"phoneExt":20,"email":63},"kenny.rodriguez-wallberg@ki.se",[65],{"facility":66,"status":20,"city":67,"state":20,"zip":68,"country":69,"countryCode":70,"cosmosGeoPoint":71,"geoPoint":76,"contacts":77},"Karolinska Institute and Karolinska University Hospital Huddinge","Stockholm","14433","Sweden","SE",{"type":72,"coordinates":73},"Point",[74,75],18.06871,59.32938,{"lat":75,"lon":74},[78,80,81],{"name":58,"role":59,"phone":79,"phoneExt":20,"email":61},"0735500118",{"name":20,"role":59,"phone":20,"phoneExt":20,"email":61},{"name":58,"role":82,"phone":20,"phoneExt":20,"email":20},"SUB_INVESTIGATOR",{"type":84,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100606983",false,"NCT07182643","Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate\u002FSevere Endometriosis Patients","An Exploratory Study of Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate\u002FSevere Endometriosis Patients: a Prospective Study","Inclusion Criteria:\n\n* Age 18-40 years old\n* Diagnosed with moderate\u002Fsevere endometriosis by ultrasound or laparoscopy (patient group)\n* Regular menstrual cycles 28-35 days\n* Speak English or Swedish and agree to participate in the study\n\nExclusion Criteria:\n\n* Pregnancy or lactation in the last 3 months\n* Uterine anomalies\n* Pelvic inflammatory disease, endometritis, STD\n* Gynaecological cancers or other malignancies in the patient's history\n* Smoking (more than 10 cigarettes per day) or alcohol abuse\n* Immunosuppressing medicines\n* Major abdominal or pelvic surgery in the last 3 months\n* A specific genetic disease that is diagnosed before PGT in women undergoing treatment",true,"FEMALE","18 Years","40 Years",{"count":96,"type":97},90,"ESTIMATED","OBSERVATIONAL","This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation. This research has the potential to uncover diagnostic indicators of impaired pre-receptive endometrium, examine pathophysiological pathways, and identify future targets for therapeutic intervention. Ultimately, the findings may contribute to more personalized fertility treatments, offering new hope for women struggling with endometriosis-related infertility.",[27],[102,103,104,105,106],"endometriosis","biomarkers","implantation","infertility","fertility","NOT_YET_RECRUITING","2025-09-16",{"date":110,"type":111},"2025-09-19","ACTUAL",{"date":113,"type":97},"2025-10-01",{"date":115,"type":97},"2027-12-31",{"name":5,"class":6},1]