[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100494096":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":39,"centralContacts":44,"locations":49,"responsibleParty":141,"collaborators":10,"id":144,"slug":10,"hasResults":145,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":151,"sex":152,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":10,"studyType":158,"phases":10,"briefSummary":159,"conditions":160,"keywords":162,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":176},{"fullName":5,"class":6},"University Hospital, Geneva","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients",null,"Patients with bleeding of unknown cause",[13,14,15,16],"Diagnostic Test: Thrombin generation","Diagnostic Test: Fibrinolysis","Diagnostic Test: Fibrin clot structure","Diagnostic Test: Coated platelets",{"label":18,"type":10,"description":19,"interventionNames":20},"Controls","Healthy voluntaries without bleeding tendency",[13,14,15,16],[22,27,31,35],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Thrombin generation","Measurement of thrombin generation by ST Genesia",[18,9],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Fibrinolysis","Measurement of fibrinolysis by Lysis Timer",[18,9],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Fibrin clot structure","Measurement of fibrin polymerisation and permeability",[18,9],{"type":23,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"Coated platelets","Measurement of coated platelets by flow cytometry",[18,9],[40],{"name":41,"affiliation":42,"role":43},"Alessandro Casini","University Hospitals of Geneva","PRINCIPAL_INVESTIGATOR",[45],{"name":41,"role":46,"phone":47,"phoneExt":10,"email":48},"CONTACT","0041223729757","alessandro.casini@hcuge.ch",[50,66,79,89,102,115,128],{"facility":51,"status":52,"city":53,"state":10,"zip":10,"country":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Ospedale Regionale di Bellinzona","RECRUITING","Bellinzona","Switzerland",{"type":56,"coordinates":57},"Point",[58,59],9.01703,46.19278,{"lat":59,"lon":58},[62],{"name":63,"role":46,"phone":64,"phoneExt":10,"email":65},"Eugenia Biguzzi","+4191811886","eugenia.biguzzi@eoc.ch",{"facility":67,"status":52,"city":68,"state":10,"zip":10,"country":54,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Inselspital - 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Universitätsspital Zürich","Zurich",{"type":56,"coordinates":132},[133,134],8.55,47.36667,{"lat":134,"lon":133},[137],{"name":138,"role":46,"phone":139,"phoneExt":10,"email":140},"Jan-Dirk Studt","+41442553488","jan-dirk.studt@usz.ch",{"type":43,"investigatorFullName":142,"investigatorTitle":143,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Casini Alessandro","Principal investigator","100494096",false,"NCT05713734","Bleeding of Unknown Cause: a Swiss Case-control Study","Bleeding of Unknown Cause, Insight Into a Multifactorial Bleeding Disorder: a Swiss Case-control Study","SWISS-BUC","Inclusion Criteria:\n\n* Man with ISTH BAT\\>3. If the calculated score includes a surgical bleeding, then two other items of the score should be \\>0\n* Woman with ISTH BAT \\>5 points. If the calculated score includes a surgical or a postpartum bleeding, then two other items of the score should be \\>0\n\nExclusion Criteria:\n\n* Ongoing pregnancy\n* Intake of antithrombotic treatment or non-steroidal anti-inflammatory drugs for least 10 days at time of blood collection\n* Intake of antifibrinolytic or blood product administration (factor concentrate, frozen fresh plasma, prothrombin complex concentrate) for least 14 days before blood collection\n* Active cancer (defined as cancer diagnosis within the last five years or treatment within the two last years before study inclusion)\n* Active autoimmune disease\n* Active chronic inflammatory disease\n* Severe liver disease (cirrhosis \\> Child A)\n* Renal insufficiency stage 3\n* Active or recent infection (within the last 30 days)\n* Recent hospitalization (\\\u003C3 months)\n* Recent surgery (\\\u003C3 months)\n* Recent trauma requiring medical intervention (\\\u003C3 months)",true,"ALL","16 Years","65 Years",{"count":156,"type":157},400,"ESTIMATED","OBSERVATIONAL","The goal of this prospective cohort is to identified specific biological patterns in patients with a bleeding of unknown cause and to study the specific mechanisms of the bleeding disorder for each subset of patients.",[161],"Bleeding Disorder",[163,164,165,28,166],"Bleeding","Hemostatics","Fibrin","Thrombin","2026-04-28",{"date":169,"type":170},"2026-04-29","ACTUAL",{"date":172,"type":170},"2023-04-01",{"date":174,"type":157},"2027-04-01",{"name":5,"class":6},7]