[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100409569":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":108,"collaborators":111,"id":114,"slug":23,"hasResults":115,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":115,"sex":120,"minAge":121,"maxAge":23,"enrollmentInfo":122,"targetDuration":23,"studyType":125,"phases":126,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":41,"whyStopped":23,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"Aarhus University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Strict BP intervention group","ACTIVE_COMPARATOR","SBP \\\u003C 120 mmHg and a reduction in SBP of \\>= 15 mmHg",[13],"Other: Blood presssure reduction",{"label":15,"type":6,"description":16,"interventionNames":17},"Conventional BP control group","In patients \\\u003C 75 years: SBP = 135 mmHg In patients \\>\u002F= 75 years: SBP = 145 mmHg",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Blood presssure reduction","Patients will be uptitrated in antihypertensive treatment until the treatment target is achieved.",[15,9],null,[25],{"name":26,"affiliation":27,"role":28},"Henrik Wiggers","Aarhus University Hospital, Department of Cardiology","PRINCIPAL_INVESTIGATOR",[30,34],{"name":31,"role":32,"phone":23,"phoneExt":23,"email":33},"Henrik Wiggers, MD, PhD","CONTACT","henrikwiggers@dadlnet.dk",{"name":35,"role":32,"phone":36,"phoneExt":23,"email":37},"Jonas A Povlsen, MD","+452270282","jonapovl@rm.dk",[39,52,64,75,86,97],{"facility":40,"status":41,"city":42,"state":23,"zip":23,"country":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Dept. of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99","RECRUITING","Aarhus","Denmark",{"type":45,"coordinates":46},"Point",[47,48],10.21076,56.15674,{"lat":48,"lon":47},[51],{"name":26,"role":32,"phone":23,"phoneExt":23,"email":23},{"facility":53,"status":54,"city":55,"state":23,"zip":23,"country":43,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Dept. of Cardiology, Herning Hospital","NOT_YET_RECRUITING","Herning",{"type":45,"coordinates":57},[58,59],8.97662,56.13615,{"lat":59,"lon":58},[62],{"name":63,"role":32,"phone":23,"phoneExt":23,"email":23},"Morten Bøttcher",{"facility":65,"status":54,"city":66,"state":23,"zip":23,"country":43,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Dept. of cardiology, Horsens Hospital","Horsens",{"type":45,"coordinates":68},[69,70],9.85034,55.86066,{"lat":70,"lon":69},[73],{"name":74,"role":32,"phone":23,"phoneExt":23,"email":23},"Karen Kaae Dodt",{"facility":76,"status":54,"city":77,"state":23,"zip":23,"country":43,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Dept. of cardiology, Randers Hospital","Randers",{"type":45,"coordinates":79},[80,81],10.03639,56.4607,{"lat":81,"lon":80},[84],{"name":85,"role":32,"phone":23,"phoneExt":23,"email":23},"Liv Gøtzsche",{"facility":87,"status":54,"city":88,"state":23,"zip":23,"country":43,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Silkeborg Hospital","Silkeborg",{"type":45,"coordinates":90},[91,92],9.54508,56.1697,{"lat":92,"lon":91},[95],{"name":96,"role":32,"phone":23,"phoneExt":23,"email":23},"Lars Frost",{"facility":98,"status":54,"city":99,"state":23,"zip":23,"country":43,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Dept. of cardiology, Viborg Hospital","Viborg",{"type":45,"coordinates":101},[102,103],9.40201,56.45319,{"lat":103,"lon":102},[106],{"name":107,"role":32,"phone":23,"phoneExt":23,"email":23},"Jens Refsgaard",{"type":109,"investigatorFullName":26,"investigatorTitle":110,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"SPONSOR_INVESTIGATOR","Consultant, Associate professor, MD, PhD, DMSc",[112],{"name":113,"class":6},"Danish Heart Foundation","100409569",false,"NCT04613193","Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis","BP-AVALVE","Inclusion Criteria:\n\n* Aortic valve peak velocity (Vmax) of 3.0-5.0 m\u002Fs and\u002For aortic valve area (AVA) ≤ 1.2 cm2\n* Blood pressure: SBP \\>= 127 mmHg measured by BP-TRU\n* LVEF ≥ 50%\n* Age \\> 18 years\n* Safe birth control management (intrauterine devices or hormonal contraceptives (contraceptive pills, implants, transdermal patches, hormonal vaginal devices or injections with prolonged release)) for women of childbearing potential.\n* Negative urine-HCG for women of childbearing potential\n* Ability to understand the written patient information and to give informed consent.\n\nExclusion Criteria:\n\n* Symptoms due to AS\n* Symptomatic orthostatic hypotension and\u002For one minute standing SBP \\\u003C 110 mmHg (16).\n* Suspicion of secondary hypertension\n* Participation in other randomized drug study (device studies accepted)\n* Moderat to severe aortic valve regurgitation e.g. vena contracta \\> 5 mm, assessed by echocardiography)\n* Known or suspected ischemic heart disease (coronary angiography with \\>70% stenosis in a major epicardial vessel, symptoms or signs of myocardial ischemia, e.g. angina pectoris, wall motion abnormalities). Patients who have previously undergone complete revascularization of major coronary arteries due to angina pectoris are eligible for inclusion.\n* Significant coronary obstructive lesions detected by baseline Cardiac CT that requires a revascularisation procedure.\n* eGFR \\\u003C 30 ml\u002Fmin or end-stage renal disease\n* Other disease, comorbidity or treatment making the subject unsuitable for study participation as judged by the investigator","ALL","18 Years",{"count":123,"type":124},200,"ESTIMATED","INTERVENTIONAL",[127],"NA","The aim of this study is to investigate the effect of strict blood pressure control versus conventional care in patients with asymptomatic moderate to severe aortic valve stenosis.\n\nThe study is a randomized (1:1), open label, controlled intervention trial.\n\nHypothesis:\n\n1. Strict BP control for 12 months reduces the progression of LV remodelling compared to conventional treatment.\n2. Strict BP control for 2 years reduces the increase in aortic valve calcification and LV remodelling compared to conventional treatment.\n3. Strict BP reduction for up to 10 years reduces the need for aortic valve replacement and cardiovascular events compared to conventional care.",[130,131,132],"Aortic Valve Stenosis","Hypertension,Essential","Heart Failure",[130,134,135],"Hypertension","Heart failure","2020-10-27",{"date":138,"type":139},"2020-11-03","ACTUAL",{"date":141,"type":139},"2019-03-01",{"date":143,"type":124},"2031-06-01",{"name":26,"class":6},6]