Health Trials

About this trial

The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:

1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.

Eligibility criteria

Qualifiers

CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or

Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)

Disqualifiers

Pre-morbid mRS ≥3

Predicted hospital system admission <72 hours

Pacemaker or other MRI contraindications per American College of Radiology guidelines

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

150 Participants
are grouped into 1 trial group

Locations

3
Yale-New Haven Hospital06510, New HavenConnecticut, United States
University of Chicago Medical Center60637, ChicagoIllinois, United States
Massachusetts General Hospital02114, BostonMassachusetts, United States

Sponsors and collaborators

Yale University

Lead sponsor

University of Chicago

Collaborator

Massachusetts General Hospital

Collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator

Source ClinicalTrials.gov