[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589596":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":35,"centralContacts":36,"locations":35,"responsibleParty":47,"collaborators":35,"id":49,"slug":35,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":35,"enrollmentInfo":57,"targetDuration":35,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":73,"whyStopped":35,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":35},{"fullName":5,"class":6},"University Hospital, Bordeaux","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Sensitizing events : Pregnancy","ACTIVE_COMPARATOR","Patients who have been pregnant",[13],"Other: Identification of types of anti-HLA-specific memory LBs",{"label":15,"type":10,"description":16,"interventionNames":17},"Sensitizing events : Previous transplantation with thrombosis","Previous transplantation with early transplantectomy due to thrombosis",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Sensitizing events : Previous transplantation with antobody","Previous transplantation with antibody-mediated rejection",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Whitout any sensitizing event","Patients who have anti-HLA antibodies without any sensitizing event identified",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Sensitizing events : Transfusion","Patients who received a blood transfusion",[13],[31],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Identification of types of anti-HLA-specific memory LBs","Using blood sample, it will be perform single cell RNA sequencing of sorted anti-HLA B cells, identified with HLA tetramers, of five groups of patients based on their immunization histories. It will be further perform a phenotypic characterization of the tetramer+ anti-HLA B cells using spectral cytometry to study their nature and identify novel markers of memory subgroups.",[9,19,15,27,23],null,[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Claire LEIBLER, MD","CONTACT","05 57 82 21 46","+33","claire.leibler@chu-bordeaux.fr",{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},"Jonathan VISENTIN, PharmD, PhD","05 57 82 24","jonathan.visentin@chu-bordeaux.fr",{"type":48,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100589596",false,"NCT06956469","BmemHLA : Origins of the Heterogeneity of the Anti-HLA Memory B Cells in Kidney Transplantation","BmemHLA","Inclusion Criteria:\n\n* Adult kidney transplantation candidate at CHU de Bordeaux\n* Sensitized against class I HLA\n* Only on type of sensitizing event among : transfusion, pregnancy, previous transplantation, no senitizing event\n\nExclusion Criteria:\n\n* Pediatric kidney transplantation candidate at CHU de Bordeaux\n* Rituximab injection\n* Ongoing treatment with immunosuppressive drugs\n* Non-cutaneous carcinoma, chronic viral infection\n* Acute infection\n* Recent vaccination (\\\u003C1 month)","ALL","18 Years",{"count":58,"type":59},75,"ESTIMATED","INTERVENTIONAL",[62],"NA","This study will describe the transcriptomic and phenotypic characteristics of anti-HLA memory B cells by comparing five groups of patients awaiting renal transplantation: patients with a single history of pregnancy, transfusion or failure of a first renal transplant requiring transplantectomy within 3 months of transplantation, or after 3 months, and patients without an immunizing allogeneic event. The hypothesis is that these five contexts induce different types of memory B cells with different modalities of reactivation and post-transplant pathogenicity.",[65,66],"Kidney Transplantation","Immunology",[68,69,70,71,72],"Kidney","Memory B Cell","Anti-HLA antibodies","Allogeneic events","Transplantation","NOT_YET_RECRUITING","2025-05-26",{"date":76,"type":77},"2025-05-28","ACTUAL",{"date":79,"type":59},"2025-06-15",{"date":81,"type":59},"2028-12-15",{"name":5,"class":6}]